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ISSN 1561-3070 (Electronic)

2014, Number 3

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Rev Cub Oftal 2014; 27 (3)

Cytomegalovirus: from primoinfection to retinitis

Rodríguez MO, Benítez CM, Ambou FI, Vilches LDC, Hernández CC, Castro MA

Language: Spanish
References: 31
Page: 439-454
PDF size: 151.18 Kb.


ABSTRACT

Once first infection occurs, cytomegalovirus (CMV) remains latent in myeloid progenitor cells and the intermittent viral relapsing proceeding from activated macrophages and dendritic cells, is controlled by strong specific viral response CD4cell y CD8-cell. CMV retinitis is characterized by spreading retinal necrosis due to viral cytopathic effect occurs in patients who have impaired T-cell function as a result of transplantation, AIDS, or immuno-suppressive treatment. The diagnosis of CMV retinitis can be confirmed by PCR amplification of viral DNA in aqueous. Updated treatment for CMV retinitis is based on the immune system recovery with highly activity anti-retroviral therapy combined with anti CMV therapy (ganciclovir, foscarnet, cidofovir and valganciclovir). CMV is also implicated in two forms of anterior segment disease in immuno-competent adults, namely CMV anterior uveitis and CMV corneal endotheliitis.


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