2015, Number 1
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Rev Cubana Hematol Inmunol Hemoter 2015; 31 (1)
Trali, a masked threat: definition, epidemiological and clinical aspects
Román TR, Fernández DND
Language: Spanish
References: 43
Page: 4-19
PDF size: 135.70 Kb.
ABSTRACT
Transfusion-related acute lung injury better known as TRALI, has not differences
with other kinds of acute respiratory distress, except for its close relation with
transfusion. It is considered among the greatest hazards on blood products use.
With its peculiar characteristics it mimics within the many factors that may trigger
an acute respiratory distress, especially among those patients at high risk for
suffering lung damage after transfusion. The main purpose of this review is to make
a recall of the existence of TRALI for those physicians who deal with high
transfusion-demanding patients or those with conditions which could represent a
risk for its development. TRALI´s main epidemiological variables (such as incidence
and mortality) show important variations among different investigations. The
criteria heterogeneity, even after the consecution of international diagnostic
consensus, has made it difficult to take advantage of the data arose from multiple
studies about its behavior, promoting the report of not a few contradictory results
on worldwide publications. Diagnosing TRALI represents a real challenge for the
clinician since it often appears within the context of various possible causes for an
acute respiratory distress. This is why TRALI is frequently overlooked or
misdiagnosed.
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