Rojas ZEM, Vázquez OJ, Tomás RC, Bernal BBC, Cruz CG, Ortega GJ, Calderón HC, Espíritu MMS

Language: Spanish
References: 11
Page: 24-30
PDF size: 246.37 Kb.

ABSTRACT

Background: Dexamethasone decreases the production of inflammatory mediators arising after a surgical stimulus, giving an improvement in postoperative pain. Objective: To determine the effect of low-dose dexamethasone as part of postoperative multimodal analgesia and its benefit by decreasing opioid consumption. Material and methods: Forty-five patients scheduled for laparoscopic cholecystectomy were randomized into three groups of 15 patients who received doses of 0.11 mg/kg, 0.20 mg/kg and placebo 60 minutes before the procedure. We measured pain with the visual analogue scale at rest and in motion at admission to the postanesthesia care unit, 30 minutes after, at discharge from the unit and 24 hours after surgery. Results: The visual analogue scale value was higher for the placebo group in relation to the dexamethasone groups of 0.11 mg/kg and 0.2 mg/kg (p = 0.001). As for rescue doses of morphine, if the value of the visual analogue scale was › 8, eight doses were needed in the placebo group, none in the 0.11 mg/kg group, and one in the 0.20 mg/kg group (p = 0.001). Conclusions: Dexamethasone at doses of 0.11 mg/kg is useful in the multimodal management of postoperative pain and decreases opioid consumption after laparoscopic cholecystectomy.

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