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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2015, Number 1

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An Med Asoc Med Hosp ABC 2015; 60 (1)

Postoperative analgesic monotherapy efficacy with intravenous paracetamol compared with intravenous ketorolac in abdominal surgery

Golzarri-Moreno M, Arriola CJ, Torres-Aguilar Y, Quintero-García MA, Alejo GJA

Language: Spanish
References: 30
Page: 12-18
PDF size: 215.04 Kb.


ABSTRACT

Background: Paracetamol has analgesic and antipyretic properties, with fewer secondary effects in comparison with nonsteroidal anti-inflammatories, which makes its a good alternative for the treatment of postoperative pain. Objective: To demonstrate that intravenous paracetamol has equivalent efficacy with ketorolac when used as monotherapy in the management of postoperative pain. Material and methods: Forty-three patients were included, aged 18 years or older, with American Society of Anesthesiologists physical status I and II, undergoing elective abdominal surgeries, which were divided in laparoscopic surgery, minor and major open surgery. Patients were divided in two groups. The study group received 1 gram intravenous paracetamol every 8 hours and the control group received 30 milligrams intravenous ketorolac every 8 hours. Both groups received analgesic rescue with 50 milligrams intravenous tramadol. The intensity of pain was determined using a visual analog scale from 0 to 10. The analgesic effectiveness was evaluated using the intensity of pain, the time to the first analgesic rescue using the intensity of pain, the time to the first analgesic rescue and the number of rescues as parameters. Results: Twenty-two patients formed part of the paracetamol group and 21 of the control group. There were no significant differences in the demographic data. The intensity of pain was not statistically significant among the groups. The time to the first rescue and the total number of rescues were not statistically significant for the total number of the surgeries, as well as for laparoscopic surgeries and minor open surgeries. The time for the first rescue in major open surgeries was statistically significant (paracetamol: mean 5.33, SD 1.53; ketorolac: mean 1.70, SD 0.45; p = 0.03). Conclusions: As a monotherapy, paracetamol has the same analgesic effectiveness as ketorolac, so it could be used for the treatment of postoperative pain.


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