Topete-Reyes JF

Language: Spanish
References: 43
Page: 105-110
PDF size: 177.20 Kb.

ABSTRACT

Renal fibrosis is characterized by the substitution of the interstitial tissue for collagen produced from a variety of cells, mainly mio-fibroblasts from an undetermined origin. The most probable candidates are the pericytes and fibroblasts which change their phenotype on the participation of molecules as a transforming growth factor β, connective tissue growth factor, platelet-derived growth factor, epidermal growth factor and angiotensin II. These molecules share intracellular signaling pathways and are able to amplify their effects mutually. Their participation has been proven in entities as diabetic nephropathy, focal and segmental glomeruloscerosis, membranous nephropathy, IgA nephropathy, crescent glomerular diseases, membranoproliferative glomerulonephritis or even the hypertensive nephroangiosclerosis. It is pretended to design new medications capable of blocking and delaying the progression of renal damage.

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