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2015, Number 1

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Rev Fac Med UNAM 2015; 58 (1)

Integral vision of the relation between VIH infection and cancer

Villegas VC

Language: Spanish
References: 88
Page: 13-28
PDF size: 552.11 Kb.


ABSTRACT

Introduction: The magnitude of the HIV infection transcends the health problem that holds, since it is the fertile ground to generate other, emerging and reemerging diseases, of equal or greater impact. In this regard, the cancer increases its incidence, severity and mortality in HIV positive patients. This association is given in the areas of epidemiology, pathogenesis, pathophysiology, clinical and therapeutic.
Methods: To update these relations are conducted an extensive literature review; apply theoretical methods such as analysis and synthesis and the historical logic.
Develop: The nexus most evident in the genesis and development of cancer was the dysfunction of the immune system, using the immunodeficiency and chronic inflammation that induces HIV. The complexity of both diseases presupposes a challenge, to the hour of handle clinic and therapeutically, requiring a paradigm shift on the part of the services of health. However, not all the elements which have emerged from the review are negative, several findings in the conduct shown benefits for HIV-positive patient with cancer. Likewise, the prevention of cancer in them is possible.
Conclusions: The relationship between HIV and cancer are supported epidemiologically, moreover, there is evidence of causality of HIV as conducive to the emergence of malignant neoplasms to cellular and molecular level in their pathogenesis. However not everything is negative there is evidence of mutual benefits to address these health problems.


REFERENCES

  1. Pol JG, Rességuier J, Lichty BD. Oncolytic viruses: a step into cancer immunotherapy. Virus Adapt Treat 2012; 4:1-21.

  2. Global Report: UNAIDS Report on the Global AIDS Epidemic 2012. Disponible en: http://www.unaids.org/ en/resources/campaigns/20121120_globalreport2012/ globalreport/ Revisado: (20 de agosto de 2013)

  3. WHO: Number of people receiving antiretroviral therapy in low and middle imcome countries, December 2012. [Citado: 20 de agosto de 2013]. Disponible en: http:// www.who.int/hiv/data/ARTmap2013.png

  4. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-90.

  5. Song Y, Samulski D, Van Dyke TA. Cancer: A Conceptual Framework. En: DeVita, Vincent T.; Lawrence, Theodore S.; Rosenberg, Steven A. Cancer: Principles & Practice of Oncology, 8th ed. New Haven: Lippincott Williams & Wilkins; 2008, p. 3-11.

  6. Lint C, Bouchat S, Marcello A. HIV-1 transcription and latency: an update. Retrovirology. 2013;10:67-73.

  7. Jafari S, Chan K, Aboulhosn K, Yip B, Lima VD, Hogg RS, et al. Trends in reported AIDS defining illnesses (ADIs) among participants in a universal antiretroviral therapy program: an observational study. AIDS Research and Therapy. 2011;8:31-36.

  8. Calabresi A, Ferraresi A, Limina RM, Donato F, Scarcella C, Vassallo F, et al. A population-based database to study malignancies in HIV-infected patients in the Local Health Unit of Brescia (Northern Italy), period 1999-2009. Epidemiol Prev. 2013;37(2-3):153-60.

  9. Cubasch H, Joffe M, Hanisch R, Schuz J, Neugut AI, Karstaedt A, et al. Breast cancer characteristics and HIV among 1,092 women in Soweto, South Africa. Breast Cancer Res Treat. 2013;140:177-86.

  10. Ellis D, Bloch M, Franic T, Agrawal S, McCann L, Cunningham N, et al. Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD). HIV Med. 2013;14(2):77-84.

  11. Nonaka M, Hashimoto Y, Takeshima S, Aida Y. The human immunodeficiency virus type 1 Vpr protein and its carboxy-terminally truncated form induce apoptosis in tumor cells. Cancer Cell International. 2009;9:20-9.

  12. Grivennikov SI, Greten FR, Karin M. Immunity, Inflammation, and Cancer. Cell. 2010;140:883-99.

  13. Mantovani A, Allavena P, Sica A, Balkwill F. Cancerrelated inflammation. Nature. 2008;454:436-44.

  14. Achenbach CJ, Cole SR, Kitahata MM, Casper C, Willig JH, Mugavero MJ, et al. Mortality after cancer diagnosis in HIV-infected individuals treated with antiretroviral therapy. AIDS. 2011;25(5):691-700.

  15. Ahmedin M, Montse J, Elizabeth G, Michael W, Thun J. Section 2: Global Cancer Incidence (Surveillance, Epidemiology, and End Results Database) En: DeVita, Vincent T.; Lawrence, Theodore S.; Rosenberg, Steven A. Cancer: Principles & Practice of Oncology, 8th ed. New Haven: Lippincott Williams & Wilkins; 2008, p. 254-74.

  16. Katlama C, Deeks SG, Autran B, Martinez-Picado J, van Lunzen J, Rouzioux C, et al. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet. 2013;381(9883):2109-17.

  17. Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, et al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol. 2012;12:607-14.

  18. Dalton-Griffin L, Kellam P. Infectious causes of cancer and their detection. J Biol. 2009;8:67-75.

  19. Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive Strategies that are Mediated by Tumor Cells. Annu Rev Immunol. 2007.25:267-96.

  20. Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ. Natural Innate and Adaptive Immunity to Cancer. Annu Rev Immunol. 2011;29:235-71.

  21. Hanahan D, Weinberg RA. Hallmarks of Cancer: The Next Generation. Cell. 2011;144:646-74.

  22. Schreiber RD, Old LJ, Smyth MJ. Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion. Science. 2011;331:1565-70.

  23. Dosne Pasqualini C. La etiología del cáncer. Vigencia de cinco paradigmas sucesivos. Medicina (B Aires). 2003; 63(6):757-60.

  24. Dosne Pasqualini C. La guerra contra el cáncer. Medicina (B Aires). 2011;71(5):3-12.

  25. Scott Killian M. Dual role of autophagy in HIV-1 replication and pathogenesis. AIDS Research and Therapy. 2012;9:16-29.

  26. Rook GA, Dalgleish A. Infection, immunoregulation, and cancer. Immunol Rev. 2011;240:141-59.

  27. Tremblay MJ. HIV-1 and pattern-recognition receptors: a marriage of convenience. Nat Immunol. 2010;11:363-5.

  28. Altfeld M, Fadda L, Frleta D, Bhardwaj N. DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol. 2011;11:176-86.

  29. Tsunetsugu-Yokota Y, Muhsen M. Development of human dendritic cells and their role in HIV infection: antiviral immunity versus HIV transmission. Front Microbiol. 2013; 4:178-5.

  30. Mogensen TH, Melchjorsen J, Larsen CS, Paludan SR. Innate immune recognition and activation during HIV infection. Retrovirology. 2010;7:54-59.

  31. Tan Q, Zhu Y, Li J, Chen Z, Han GW, Kufareva I, et al. Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex. Science 2013; Science DOI: 10.1126/science.1241475.

  32. Jovena J, Menendezb JA. Infección por el virus de la inmunodeficiencia humana como modelo de envejecimiento prematuro: perspectivas e implicaciones. Med Clin. 2012;139(6):249-51.

  33. Lee JH, Budanov AV,Park EJ, Birse R, Kim TE, Perkins GA, et al. Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies. Science. 2010;327:1223-8.

  34. Bland ML, Birnbaum MJ. Adapting to Energetic Stress. Science. 2011;332(6036):1387-8.

  35. Berenguera J, Lagunab F, López-Aldeguerc J, Morenod S, Arribase JR, Arrizabalagaf J, et al. Prevention of opportunistic infections in HIV-infected adolescents and adults Recommendations of GESIDA/National AIDS Plan. Enferm Infecc Microbiol Clin. 2004;22(3):160-76.

  36. Estébanez M, Soto CI, Ríos JJ, Arribasa JR. Actualización en la patología pulmonar relacionada con la infección VIH. Arch Bronconeumol. 2012;48(4):126-32.

  37. Epple HJ, Zeitz M. HIV infection and the intestinal mucosal barrier. Ann New York Academy Sciences. 2012; 1258(1):19-24.

  38. Benecke A, Gale M, Jr., Katze MG. Dynamics of innate immunity are key to chronic immune activation in AIDS. Curr opin HIV/AIDS. 2012;7(1):79-85.

  39. Singh KK, Nathamu S, Adame A, Alire TU, Dumaop W, Gouaux B, et al. Expression of mannose binding lectin in HIV-1-infected brain: implications for HIV-related neuronal damage and neuroAIDS. Neurobehav HIV Med. 2011;3:41-52.

  40. Meijide H, Mena A, Pernas B, Castro A, López S, Vázquez P, et al. Neoplasias en pacientes con infección por VIH. Estudio descriptivo de 129 casos en el período 1993-2010. Rev chil Infectol. 2013;30(2):1-12.

  41. Yanik EL, Napravnik S, Cole SR, Achenbach CJ, Gopal S, Olshan A, et al. Incidence and Timing of Cancer in HIVInfected Individuals Following Initiation of Combination Antiretroviral Therapy. Clin Infect Dis. 2013;57(5):756-64.

  42. Hessol NA, Holly EA, Efird JT, Minkoff H, Schowalter K, Darragh TM, et al. Anal intraepithelial neoplasia in a multisite study of HIV-infected and high-risk HIV-uninfected women. AIDS. 2009;23(1):59-70.

  43. Boulanger E, Gerard L, Gabarre J, Molina JM, Rapp C, Abino JF, et al. Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS. J Clin Oncol. 2005;23(19):4372-80.

  44. Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM, et al. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS. 2006; 20:1645-54.

  45. Schmidt C. The Cancer–HIV/AIDS Treatment Conundrum. J Natl Cancer Inst. 2010;102(21):1615-7.

  46. Frederica A, Gomes AT, Bonecini MG. Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection – Review. Mem Inst Oswaldo Cruz. 2005;100(1):1-12.

  47. Kuritzkes DR, Walker BD. HIV-1: Pathogenesis, Clinical Manifestations, and Treatment. En: Knipe, David M.; Howley, Peter M. Fields Virology, 5th Ed. Boston: Lippincott Williams & Wilkins; 2007, p. 2188-2206.

  48. Kao J, Chen CT, Tong CC, Packer SH, Schwartz M, Chen SH, et al. Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases : Final report of a prospective clinical trial. Targ Oncol. 2013; DOI 10.1007/s11523-013-0280-y.

  49. Tornatore M, Gonçalves CV, Steigleder M, Nunes F, Xavier A, Alves M, et al. Co-infections associated with human immunodeficiency virus type 1 in pregnant women from southern brazil: high rate of intraepithelial cervical lesions. Mem Inst Oswaldo Cruz. 2012;107(2):205-10.

  50. Ogino S, Galon J, Fuchs CS, Dranoff G. Cancer immunology- analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol. 2011;8:711-9.

  51. Desmetz C, Mange A, Maudelond T, Solassol J. Autoantibody signatures: progress and perspectives for early cancer detection. J Cell Mol Med. 2011; 15(10):2013-24.

  52. Libera M, Kmieciak M, Idowu MO, Manjili R, Zhao Y, Grimes M, et al. A signature of immune function genes associated with recurrence-free survival in Breast cancer patients. Breast Cancer Res Treat. 2012;131:871-80.

  53. Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secret ally: immunostimulation by anticancer drugs. Nature Rev. 2012;11:215-33.

  54. Immunotherapy of Cancer in 2012. CA Cancer J Clin. 2012; 61:1-27.

  55. Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P, Ferrone S. Adler EM. Making Immunological Memories. Sci Signal. 2009;2(78):225-32.

  56. Hand TW, Kaech SM. CD8 T-cell differentiation. Decreasing the TORC on memory CD8 T-cell formation. Immunol Cell Biol. 2009;87:571-3.

  57. Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nature Rev. 2012;12:252-64.

  58. Schlom J. Therapeutic Cancer Vaccines: Current Status and Moving Forward. J Natl Cancer Inst. 2012;104:599- 613.

  59. Check E. Stem-cell transplants may purge HIV. Disponible en: http://www.nature.com/news/stem-cell-transplants- may-purge-hiv-1.13297#auth-1 Revisado: (27 de agosto de 2013)

  60. Gills JJ, LoPiccolo J, Tsurutani J, Shoemaker RH, Best C, et al. Mones S. Abu-Asab3, Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo. Clin Cancer Res. 2007;13:5183-90.

  61. Gills JJ, Lopiccolo J, Dennis PA. Nelfinavir, a new anticancer drug with pleiotropic effects and many paths to autophagy. Autophagy. 2008; ¡4(1):107-9.

  62. Darini CY, Martin P, Azoulay S, Drici MD, Hofman P, Obba S, et al. Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential. Cell Death Dis. 2013;4:706-18.

  63. McLean K, VanDeVen NA, Sorenson DR, Daudi S, Liu JR. The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells. Gynecol Oncol. 2009;112(3):623-30.

  64. Espantoso M. El rol de la nutrición en la etiología del cáncer. Renut. 2011;5(18):921-9.

  65. Persival SS. Nutrition and Immunity: Balancing Diet and Immune Function. Nutr Today. 2011;46(1):12-7.

  66. Russell M, Raheja V, Jaiyesimi R. Human papillomavirus vaccination in adolescence. 2013. [Citado: 29 de agosto de 2013] Disponible en: http://rsh.sagepub.com/content/ early/2013/09/04/1757913913499091.long.

  67. Eisenstein M. Public health: Prevention comes of age. Nature. 2012;488:11-13.

  68. Corona T, Román GC. Multiple Sclerosis in Latin America. Neuroepidemiology. 2006;26:1-3.

  69. Tsang BK, Macdonell R. Multiple sclerosis, Diagnosis, management and prognosis. Aust Fam Physician: 40;12:948-55.

  70. Rivera VM. Esclerosis múltiple en Latinoamérica. Rev Española de Esclerosis Múltiple. 2008;9:17-23.

  71. Compston A. McAlpine’s multiple sclerosis. Philadelphia: Elsevier/Churchill Livingstone, 2006.

  72. Sadovnick AD, Ebers GC, Wilson RW, Paty DW. Life expectancy in patients attending multiple sclerosis clinics. Neurology. 1992;42:991-4.

  73. Bronnum-Hansen H, Koch-Henriksen N, Stenager E. Trends in survival and cause of death in Danish patients with multiple sclerosis. Brain 2004;127:844-50.

  74. Corona-Vázquez T, Flores-Rivera JJ. Esclerosis múltiple. Epidemiología. Ed Med Panam. 2010:7-25.

  75. Finlayson M, Cho CA. A descriptive profile of caregivers of older adults with MS and the assistance they provide. Disability and Rehabilitation. 2008;30(24):1848-57.

  76. Kobelt G, Berg J, Atherly D, Hadjimichael O. Costs and quality of life in multiple sclerosis: a cross-sectional study in the United States. Neurology. 2006;66:1696-702.

  77. Miljković Z, Momčilović M, Miljkovic D, Mostarica-Stojković M. Methylprednisolone inhibits IFN-γ and IL-17 expression and production by cells infiltrating central nervous system in experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2009;6:37. Disponible en: http://www.jneuroinflammation.com/content/6/1/37/

  78. Rudick R, Bruce D. Gray-Metter Injury in Multiple Sclerosis. N Engl J Med. 2009;361(15):1505-6.

  79. Pelletier D, Hafler DA. Fingolimod for Multiple Sclerosis. New England Journal of Medicine. 2012;366:339-47.

  80. Then-Bergh F, Kümpfel T, Schumann E, Held U, Schwan M, Blazevic M, et al. Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations. BMC Neurology. 2006;9:19.

  81. Lyons PR, Newman PK, Saunders M. Methylprednisolone therapy in multiple sclerosis: a profile of adverse effects. Journal of Neurology, Neurosurgery, and Psychiatry. 1988; 51:285-7.

  82. Takahashi A, Kanno Y, Takahashi Y, Sakamoto N, Monoe K, Saito H, et al. Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: A case report. World J Gastroenterol. 2008;14(35):5474-7.

  83. Castillo M. Transtornos de la sustancia blanca. En: Neurorradiología. Ed. Journal. 2004. pp 70-74.

  84. Yousry TA, Filippi M, Becker C, et al. Comparison of MR pulse sequences in the detección of multiple sclerosis lesions. AJNR Am J Neuroradiol. 1997;18:959-63.

  85. Horowitz AL, Kaplan RD, Grewe G y cols. The ovoid lesion: a new MR observation in patients with multiple sclerosis. AJNR Am J Neuroradiol 1989;10:303-305.

  86. Alam SM, Kyriakides T, Lawden M, Newman PK. Methylprednisolone in multiple sclerosis: a comparison of oral with intravenous therapy al equivalent high dose. Journal of Neurology, Neurosurgery and Psychiatry. 1993; 56:1219-20.

  87. Elliott C, Lindner M, Arthur A, et al. Functional identification of pathogenic autoantibody responses in patients with multiple sclerosis. Brain. 2012:135;1819-33.

  88. Katzman GL. Multiple Sclerosis. En: Osborn AG, Blaser SI, Salzman KL, Katzman GL, Provenzale J, Castillo M, et al. Diagnostic Imaging, Brain. Salt Lake City, Utah: Amyrsis, 2004. I-8. pp. 74. La barrera hematoencefálica mejora con los bolos de MP, debido a la exposición crónica y regular a éstos con dosis bajas e intervalos cada vez más amplios. Este argumento tiene fundamento al saber que al atenuar el sistema inmune de manera regular, aun cuando el paciente no tenga recaídas, logramos la estabilización de cascadas y factores proinflamatorios y con ello se da un menor índice de recaídas y un menor daño a largo plazo (principalmente cognitivo), lo que es muy válido para los pacientes donde la causa es la activación del sistema inmune.




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