2014, Number 4
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Rev Esp Med Quir 2014; 19 (4)
Homocysteine and lipid profile in normal pregnancy and pregnancy complicated with preeclampsia
Canto-Cetina T, Polanco-Reyes L, Ballote-Zapata M, Ordóñez-Luna M
Language: Spanish
References: 54
Page: 423-430
PDF size: 472.06 Kb.
ABSTRACT
Background: Preeclampsia (PE) is one of the most common and severe
complications of pregnancy. It is responsible for highest rates of morbidity
and mortality for both mother and the neonate. Previous studies have
produced contradictory findings regarding total homocysteine (Hcy)
levels in women with preeclampsia/eclampsia and there is little information
about the relationship between particular serum lipids and Hcy.
Methods: Case-control study of 595 patients: 285 pregnant women with
preeclampsia as cases and 310 healthy pregnant women as controls.
Blood sera obtained from patients and controls attending the Hospital
Materno-Infantil Secretaría de Salud de Yucatán were analyzed for
tHc, total cholesterol, triglycerides, low-density lipoprotein (LDL-C)
and high-density lipoprotein (HDL-C).
Results: Mean level of homocysteine was significantly higher in preeclamptic
women than in control group and mean HDL-C concentrations
were lower in cases than in controls.
Conclusion: We found significant association of preeclampsia with
elevated levels of homocysteine and low levels of HDL-C.
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