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2014, Number 2

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Rev Cub Med Mil 2014; 43 (2)

Adverse reactions to drugs in a surgical emergency unit

González GML, Puga TMS, Lara FH, Miranda GO, Labañino CA

Language: Spanish
References: 33
Page: 216-227
PDF size: 93.11 Kb.


ABSTRACT

Introduction: adverse drug reactions in surgical units constitute a health problem little known, so there is little research concerning this topic.
Objective: to characterize adverse drug reactions in patients operated on at the Surgical Emergency Unit of "Dr. Luis Díaz Soto" Central Military Hospital.
Methods: a prospective, observational study was conducted using active and passive methods of Drug Safety. The sample consisted of 2128 patients operated in 2010.These patients were monitored daily through a counseling list of syndromes for adverse reactions and by health professional reports.
Results: out of the patients operated on, 65 (3.05 %) had at least one adverse drug reaction with a rate of occurrence of 1.12 %. Most reports were in patients aged 45- 59 years (40.0 %) and female (69.2 %). the highest rate of reporting was contributed by general anesthetics and antimicrobial (36.9 % and 18.5 % respectively); cefazolin and ketamine were the most reported drugs with 13.8 %. Skin was the most affected organ system and skin rash was the most common clinical manifestation (17.8 %). Moderate adverse reactions occurred more frequently.
Conclusions: the importance of pharmacovigilance is highlighted, especially in sensitive areas such as surgical units, where adverse drug reactions are common.


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