2005, Number 4
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Vet Mex 2005; 36 (4)
Relationship between structure and function of receptors for steroid hormones: Estrogen receptors
Pérez-Rivero JJ, Aguilar-Setién A, Villa-Godoy A, Serrano H
Language: English/Spanish
References: 49
Page: 437-452
PDF size: 575.28 Kb.
ABSTRACT
Functions exerted by estrogens in animal reproduction are tuned delicately by various mechanisms, among them, specific receptors for estrogens are paramount. Recently developed techniques for biochemical and genetic molecular studies led to the discovery of the modular structure of the nuclear receptors. A notorious group of this type of receptors is the estrogen-receptor family (ER). Each module has a unique structural composition that allows interaction with a variety of molecules. As a result of this interaction between the receptor and the molecules, several effects are elicited, some of them are inhibitory while others are stimulatory of the transcription rate. Indeed, some of the reactions resulting from a synthetic ligand-receptor interaction are as unexpected as the conformational change of the ER three-dimensional structure, allowing the ER itself to exert functions that are not described in the classical review articles on this topic. In the present review, we established a connection among structure, function and regulatory mechanisms of the nuclear receptors, emphasizing the ER, to make this information available to a broad spectrum of readers.
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