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2014, Number 2

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Rev cubana med 2014; 53 (2)

Rapid development of resistance to antiretroviral drugs in two patients infected with HIV-1

Díaz THM, Machado ZLY, Dubed EM, Martínez FL, Ruiz GNM, Blanco AM

Language: Spanish
References: 19
Page: 127-133
PDF size: 74.97 Kb.


ABSTRACT

Introduction: the use of antiretroviral therapy has facilitated the slow and partial recovery of the immune system, allowing to reduce opportunistic complications, to increase survival and to improve quality of life in patients infected with human immunodeficiency virus type 1.
Objective: to determine rapid evolving viral variants with resistance to antiretroviral drugs in HIV-1 positive patients.
Methods: two HIV-1 positive patients were studied. They were appointed by the letters A and B, respectively, and antiretroviral drug resistance were determined at two different times: Moment of diagnosis and 2012. Results were related to clinical variables.
Results: at the time of diagnosis Patient A had subtype BG virus with low levels of resistance to zidovudine and stavudine. Patient B had subtype B virus with low levels of resistance to zidovudine. In 2012, the patient A showed FRC18-cpx viral variant with high levels of resistance to lamivudine, emtricitabine, and nevirapine. Patient B remained infected with subtype B virus, but resistant to the reverse transcriptase inhibitors.
Conclusions: these results show the dynamic and rapidly evolving variants of HIV-1 infected patients.


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