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2014, Number 5

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Gac Med Mex 2014; 150 (5)

Signaling mechanisms involved in resolution of inflammation

Cervantes-Villagrana RD, Cervantes-Villagrana AR, Presno-Bernal JM

Language: Spanish
References: 57
Page: 440-449
PDF size: 516.40 Kb.


ABSTRACT

Inflammation is a physiological process, which eliminates pathogens and induces repair of damaged tissue. This process is controlled by negative feedback mechanisms, but if the inflammation persists, it generates a deleterious autoimmune process or can to contribute with diseases such as obesity or cancer. The inflammation resolution involves mechanisms such as decrease of proliferation and maturation of immune cells, phagocytosis and apoptosis of immune cells, and decrease of proinflammatory mediators. Therefore, is relevant to study the physiological effects of specific receptors that participate in inflammation resolution and the design of specific agonists as conventional anti-inflammatory therapeutics, without dramatic collateral effects. In this review, we study some mechanisms associated with inflammation inhibition, particularly the transduction of receptors for ligands with anti-inflammatory effects and that are relevant for their potential therapeutic.


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