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ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2014, Number 3

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Acta Med Cent 2014; 8 (3)

Determinants in overall survival in invasive breast carcinomas clinical and morphological prognostic factors. Assessment of tumor volume

Ruiz JL, Alegret RM, Llombart-Bosh A, Machado PI, Ramos VJ

Language: Spanish
References: 28
Page: 37-47
PDF size: 178.15 Kb.


ABSTRACT

The clinical and morphological prognostic factors were evaluated regarding their predictive capacity on the evolutionary appearance of death in patients with invasive breast carcinoma. Material and method: a nonrandom sample of 373: it was defined a women with invasive breast carcinomas by a period of 15 years (1992-2007). Results: the death event occurred more frequently before the first five years of evolution. 87 patients died with an overall survival of 76.7% and an average of 13.53 years. From the evaluated factors the most contributed to overall survival were: tumor position in the lower inner quadrant, with 21patients -10 of them died, 52.4% overall survival and an average of 4.35 years; bilateralism, with 12 patients –seven of them died, 41.7% overall survival and an average of 7.27 years; tumor volume of more than 125cm3, with six patients – three died, 50.0% survival and an average of 8.87 years; nodal status with more than three metastatic nodes, with 77 patients -33 died, 57.1% overall survival and an average of 8.54 years; the presence of periganglionar infiltration tumor, with 72 patients -31 dead, 56.9% of overall survival and an average of 8.63 years; involvement of level III, with 53 patients died -20 died, 62.3% survival and an average of 9.47 years; the modified histological grade poorly differentiated, with 116 patients -41 died, 64.7% overall survival and an average of 11.84 years and the mitotic count with more than 22 mitoses per field further increase with 65 cases -26 dead, 60.0% overall survival and an average of 11.24 years. Conclusion: tumor volume can be considered a morphological prognosis factor determinant in overall survival in infiltrating breast cancer.


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