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ISSN 2070-8718 (Print)

2010, Number 1

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Rev Cub Gen 2010; 4 (1)

Oxidative damage and antioxidant enzymes in blood of patients with Spinocerebellar Ataxia Type 2

Riverón FG, Martínez BO, Gutiérrez GR, Pandolfi BA, Pupo BJ, Pereira N, Velazquez PL

Language: English
References: 33
Page: 42-47
PDF size: 313.62 Kb.


ABSTRACT

Recent evidences suggest that increased oxidative damage as well as deficits in antioxidants defense systems could be related to the pathogenesis of some hereditary ataxias. The aim of this study was to investigate some redox status biomarkers in patient with spinocerebellar ataxia type 2. Samples from 33 patients and 22 control subjects, from Holguín province, were used to determined plasmatic levels of malondialdehyde and enzymatic activities of Cu/Zn superoxide dismutase and catalase by spectrophotometric methods. Besides, DNA damage in peripheral blood cells was evaluated using the Comet assay. Our results evidenced that oxidative damage is higher in spinocerebellar ataxia type 2 Cuban patients in comparison with the control group. In addition, we found an increase of antioxidant activity of evaluated enzymes in affected subjects. These findings suggest that the systemic redox state is altered in patients with spinocerebellar ataxia type 2.


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