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Academia Mexicana de Neurología, A.C.

2014, Number 3

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Rev Mex Neuroci 2014; 15 (3)

Usefulness of trihexyphenidyl in the prevention of movement disorders induced by typical neuroleptics

Scherle-Matamoros CE, Terroba-Chambi CJ, Marot-Casañas M

Language: Spanish
References: 18
Page: 147-151
PDF size: 124.35 Kb.


ABSTRACT

Introduction: Drugs with anticholinergic effects have been considered for many years as first-line medications for treatment and prevention of movement disorders induced by neuroleptics. However, its usefulness is not well established.
Objetive: To describe the experience with trihexyphenidyl therapy for the prevention of dyskinesias in patients with chronic psychosis medicated with classical antipsychotic drugs.
Methods: A quasi-experimental, observational study was performed on patients with chronic psychosis medicated with fluphenazine decanoate and other neuroleptics, under treatment or not with trihexyphenidyl.
Results: A total of 64 patients were included, among whom schizophrenia predominated; 56.2% (36 cases) was medicated with trihexyphenidyl from the start of treatment with fluphenazine decanoate. The mean treatment period was 66.9 months. In 60.9% (39 patients) some variant of movement disorders were found and these were more frequent in cases medicated with trihexyphenidyl (61.5 vs. 38.5%). The predominant movement disorders were parkinsonism (n = 19, 29.7%), followed by akathisia (n = 7, 10.9%) and tardive dyskinesia (n = 4, 11.1%).
Conclusion: In this observational study it was not evidenced the usefulness of trihexyphenidyl in the prophylaxis of neurolepticinduced dyskinesias.


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