Torres FJ, Jave SLF

Language: Spanish
References: 54
Page: 439-446
PDF size: 442.38 Kb.

ABSTRACT

Homeobox genes encode proteins named transcription factors, which are responsible for regulating gene transcription by binding to different genes to promote or block their expression. Deregulation of transcription factors is related to various neoplastic processes. MEIS1 gene encoding the transcription factor of the same name, participates in the early stages of hematopoiesis, maintaining stem cells in undifferentiated state and favoring its proliferation. Overexpression of MEIS1 gene accelerates the development of hematological malignancies and is also a poor prognostic factor in patients with leukemia.

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