medigraphic.com
Colegio de Medicos y Cirujanos República de Costa Rica

2014, Número 611

<< Anterior Siguiente >>

Rev Med Cos Cen 2014; 71 (611)


Polimorfismos -308 G ›A y -238 G ›A del gen TNF- α en aborto recurrente

Alonso BSA, Gutiérrez ABE, Salazar DIM, Aceves AMA, Dávalos NO, Dávalos RIP

Idioma: Español
Referencias bibliográficas: 39
Paginas: 431-437
Archivo PDF: 244.51 Kb.


RESUMEN

El aborto recurrente (AR) es la pérdida de dos o más embarazos antes de la semana 20 semanas de gestación. Los AR se pueden atribuir a diversas causas tales como endócrinas, genéticas, factores anatómicos e inmunológicos, entre otros. A pesar de que varios factores etiológicos ya están bien establecidos, en el 50% de los casos de AR se desconoce la causa. Investigaciones previas han asociado algunas citocinas a AR. El factor de necrosis tumoral alfa (TNF-α) es una citocina proinflamatoria y se ha relacionado en estudios previos a AR, así como su implicación en la etapa temprana del embarazo. Los polimorfismos -308 G›A (rs1800629) y -238 G›A (rs361525) se han descrito en la región promotora del gen TNF-α. En el presente trabajo se realiza una revisión de estudios previos de asociación de los polimorfismos -308 G›A y -238 G›A en la región promotora del gen del TNF-α con AR.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Alijotas-Reig J, Garrido-Gimenez C. Current concepts and new trends in the diagnosis and management of recurrent miscarriage. Obstet Gynecol Surv. 2013; 68(6):445-66.

  2. Anderson GM, Nalara MT, De Write M, Tumor necrosis factor-alpha in the pathogenesis and treatment for cancer. Curr Opin Pharmacol. 2004; 43:4-20

  3. Babbage SJ, Arkwright PD, Vince GS, Perrey C, Pravica V, Quenby S, Bates M, Hutchinson IV. Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss. J Reprod Immunol. 2001;51(1):21-7.

  4. Bates MD, Quenby S, Takakuwa K, Johnson PM, Vince GS. Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss. Hum Reprod. 2002; 17(9):2439-44.

  5. Baxter N, Sumiya M, Cheng S, Erlich H, Regan L, Simons A, Summerfield JA. Recurrent miscarriage and variant alleles of mannose binding lectin, tumour necrosis factor and lymphotoxin alpha genes. Clin Exp Immunol. 2001; 126(3):529-34.

  6. Branch D.W., Gibson M., Silver R.M. Clinical practice. Recurrent miscarriage. Engl J Med. 2010; 363(18):1740-7.

  7. Calleja-Agius J, Jauniaux E, Pizzey AR, Muttukrishna S. Investigation of systemic inflammatory response in first trimester pregnancy failure. Hum Reprod. 2012; 27(2):349-57.

  8. Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA. Cytokinedependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]. J Immunol. 1998; 160(2):545-9..

  9. Christiansen OB, Nielsen HS, Kolte AM. Inflammation and miscarriage. Semin Fetal Neonatal Med. 2006; 11(5):302-8.

  10. Christiansen OB. Mol Immunol. 2013; 55(1):8-15.

  11. Daher S, Shulzhenko N, Morgun A, Mattar R, Rampim GF, Camano L, DeLima MG. Associations between cytokine gene polymorphisms and recurrent pregnancy loss. J Reprod Immunol. 2003; 58(1):69-77.

  12. El-Far M, El-Sayed H, El-Monwally AE, Hashem IA, Bakry N. Serum levels of TNF-alpha and antioxidant enzymes and placenta TNF-alpha expression in unexplained recurrent spontaneous miscarriage. J Physiol Biochem. 2009; 65(2):175-81.

  13. Garcia-Lloret MI, Winkler- Lowen B, Guilbert LJ. Monocytes adhering by LFA-1 to placental syncytiotrophoblasts induce local apoptosis via release of TNF-alpha. A model for hematogenous initiation of placental inflammations. J Leukoc Biol. 2000; 68(6):903-8.

  14. Gupta R, Prakash S, Parveen F, Agrawal S. Association of CTLA- 4 and TNF-α polymorphism with recurrent miscarriage among North Indian women. Cytokine. 2012; 60(2):456-62.

  15. Herrmann SM, Ricard S, Nicaud V, Mallet C, Arveiler D, Evans A, Ruidavets JB, Luc G, Bara L, Parra HJ, Poirier O, Cambien F. Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity. Eur J Clin Invest. 1998; 28(1):59-66.

  16. Kaur A, Kaur A. Recurrent pregnancy loss: TNF-α and IL-10 polymorphisms. J Hum Reprod Sci. 2011; 4(2):91-4.

  17. Kwak-Kim JY, Gilman-Sachs A, Kim CE. T helper 1 and 2 immune responses in relationship to pregnancy, nonpregnancy, recurrent spontaneous abortions and infertility of repeated implantation failures. Chem Immunol Allergy. 2005; 88:64-79.

  18. Larsen EC, Christiansen OB, Kolte AM, Macklon N. New insights into mechanisms behind miscarriage. BMC Med. 2013;26;11:154.:

  19. Liu C, Wang J, Zhou S, Wang B, Ma X. Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNFalpha) v and unexplained recurrent spontaneous abortion (URSA) in Chinese population. Reprod Biol Endocrinol. 2010; 8:114.

  20. Mekinian A, Tamouza R, Pavy S, Gestermann N, Ittah M, Mariette X, Miceli-Richard C. Functional study of TNF-α promoter polymorphisms: literature review and meta-analysis. Eur Cytokine Netw. 2011; 22(2):88- 102.

  21. Nedwin GE, Naylor SL, Sakaguchi AY, Smith D, Jarrett-Nedwin J, Pennica D, Goeddel DV, Gray PW. Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res. 1985; 13(17):6361-73.

  22. Oregón-Romero E, Vázquez-Del Mercado M, Ruiz-Quezada SL, Navarro-Hernández RE, Rangel- Villalobos H, Martínez-Bonilla G, Bernard-Medina AG, Armendáriz- Borunda J, García-Bañuelos J, Muñoz-Valle JF Tumor necrosis factor alpha-308 and -238 polymorphisms in rheumatoid arthritis. Association with messenger RNA expression and sTNF-alpha. J Investig Med. 2008; 56(7):937-43.

  23. Palmirotta R, La Farina F, Ferroni P, Ludovici G, Nigro C, Savonarola A, Raparelli V, Riondino S, Rampini MR, Guadagni F, Basili S. TNFA gene promoter polymorphisms and susceptibility to recurrent pregnancy loss in Italian women. Reprod Sci. 2010; 17(7):659-66.

  24. Pietrowski D, Bettendorf H, Keck C, Bürkle B, Unfried G, Riener EK, Hefler LA, Tempfer C. Lack of association of TNFalpha gene polymorphisms and recurrent pregnancy loss in Caucasian women. J Reprod Immunol. 2004; 61(1):51- 58.

  25. Piosik ZM, Goegebeur Y, Klitkou L, Steffensen R, Christiansen OB Plasma TNF-α levels are higher in early pregnancy in patients with secondary compared with primary recurrent miscarriage. Am J Reprod Immunol. 2013; 70(5):347-58.

  26. Prigoshin N, Tambutti M, Larriba J, Gogorza S, Testa R. Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause. Am J Reprod Immunol. 2004; 52(1):36-41.

  27. Quintero-Ramos A, Valdez- Vélázquez LL, Hernández G, Baltazar LM, Padilla-Gutiérrez JR, Valle Y, Rodarte K, Ortiz R, Ortiz-Aranda M, Olivares N, Rivas F. Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion]. Gac Med Mex. 2006; 142(2):95-8.

  28. Raghupathy R, Kalinka J. Cytokine imbalance in pregnancy complications and its modulation. Front Biosci.2008;13:985-94

  29. Rai R, Regan L. Recurrent miscarriage. Lancet. 2006; 368(9535):601-11.

  30. Reid JG, Simpson NA, Walker RG, Economidou O, Shillito J, Gooi HC, Duffy SR, Walker JJ. The carriage of pro-inflammatory cytokine gene polymorphisms in recurrent pregnancy loss. Am J Reprod Immunol. 2001; 45(1):35-40.

  31. Rull K, Nagirnaja L, Laan M. Genetics of recurrent miscarriage: challenges, current knowledge, future directions. Front Genet. 2012; 3: 34.

  32. Saini V, Arora S, Yadav A, Bhattacharjee J. Cytokines in recurrent pregnancy loss. Clin Chim Acta. 2011; 412(9-10):702-8.

  33. Toth B, Jeschke U, Rogenhofer N, Scholz C, Würfel W, Thaler CJ, Makrigiannakis A. Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol. 2010; 85(1):25-32.

  34. Toder V, Fein A, Carp H, Torchinsky A. TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?. J Assist Reprod Genet. 2003; 20(2):73-81.

  35. Wang AM, Creasey AA, Ladner MB, Lin LS, Strickler J, Van Arsdell JN, Yamamoto R, Mark DF. Molecular cloning of the complementary DNA for human tumor necrosis factor. Science. 1985; 228(4696):149-54.

  36. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A. 1997; 94(7):3195-9

  37. Wold AS, Arici A. Natural Killer cells and reproductive failure. Curr Opin Obstet Gynecol, 2005; 17(3);237-41.

  38. Zhang B, Liu T, Wang Z. Association of tumor necrosis factor-α gene promoter polymorphisms (-308G/A, -238G/A) with recurrent spontaneous abortion: a meta-analysis. Hum Immunol. 2012;73(5):574-9.

  39. Zammiti W, Mtiraoui N, Khairi H, Gris JC, Almawi WY, Mahjoub T. Associations between tumor necrosis factor-alpha and lymphotoxin-alpha polymorphisms and idiopathic recurrent miscarriage. Reproduction. 2008; 135(3):397-403.




2020     |     www.medigraphic.com