Torres FJ, Jave SLF

Idioma: Español
Referencias bibliográficas: 54
Paginas: 439-446
Archivo PDF: 442.38 Kb.

RESUMEN

Los genes homeobox codifican proteínas denominadas factores de transcripción, encargadas de la regulación de la transcripción genética, uniéndose a diversos genes para favorecer o bloquear su expresión. La desregulación de estos factores de transcripción está relacionada con diversos procesos neoplásicos. MEIS1 es un gen que codifica para el factor de transcripción del mismo nombre, el cual participa en las etapas tempranas de la hematopoyesis manteniendo a las células madre en un estado indiferenciado y favoreciendo su proliferación. La sobreexpresión de este gen acelera el desarrollo de neoplasias hematológicas y además es un factor de mal pronóstico en pacientes con leucemias.

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