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Colegio de Medicos y Cirujanos República de Costa Rica

2014, Number 611

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Rev Med Cos Cen 2014; 71 (611)

Polimorfismos -308 G ›A y -238 G ›A del gen TNF- α en aborto recurrente

Alonso BSA, Gutiérrez ABE, Salazar DIM, Aceves AMA, Dávalos NO, Dávalos RIP

Language: Spanish
References: 39
Page: 431-437
PDF size: 244.51 Kb.


ABSTRACT

Recurrent abortion (RA) is the loss of two or more pregnancies before 20 weeks of gestation. The RA can be attributed to several causes such as endocrine, genetic, anatomical and immunological factors, among others. Although various etiological factors are well established, in 50 % of cases of RA cause is unknown. Previous investigations have associated some cytokines to RA. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine related in previous studies to RA, and involvement in early stage of pregnancy. -308 G›A (rs1800629) and -238 G›A (rs361525) polymorphisms have been described in the promoter region of TNF-α gene. The present work is a review from previous reports of the association of the -308 G›A and -238 G›A polymorphisms in the promoter region of TNF-α gen and RA.


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