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2014, Number 2

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Investigación en Discapacidad 2014; 3 (2)

Osteoarthritis, obesity and inflammation

Duarte-Salazar C, Miranda-Duarte A

Language: Spanish
References: 42
Page: 53-60
PDF size: 195.67 Kb.


ABSTRACT

Obesity is a yield point in onset for osteoarthritis. However, in spite of its straight effect on weight-bearing joints, it is not likely enough to justify osteoarthritis by itself. Recent evidence has demonstrated some correlationship among obesity and osteoarthritis in hands, no easy to explain by weight-bearing. It is realized that metabolic factors parallel to obesity may influence on osteoarthritis. White fat tissue is an active producer of adipokines, which are proteins involved in active communication between adipocites and immunologic cells, evolving into an inflammatory articular response. New adipokines are currently under study besides those well documented such as leptine, adiponectine and resistine. An important role is played by adipokine proteins in other metabolic and cardiovascular complications, correlated to obesity, osteoarthritis and rheumatic diseases. Present paper intends to enhance comprehension of osteoarthritis and its relationship to obesity and in particular with the study of adipokines.


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