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ISSN 0016-3813 (Print)

2005, Number 2

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Gac Med Mex 2005; 141 (2)

Autism

Rogel-Ortiz FJ

Language: Spanish
References: 53
Page: 143-148
PDF size: 47.08 Kb.


ABSTRACT

Autism is a static, neuro-developmental disorder, that is life-long and comprises a wide range of behavioral disorders. It has a prevalence of 1-2 per 1,000 with a broad range of severity. Multiple causes have been put forward and genetics plays the major role. According to DSM-IV the main clinical manifestations include impaired social skills, language and non-verbal communication and changes in range of interests and activities. Cognitive deficits are frequent but not universal. Perseveration, affective flatness and lack of insight into other people´s thinking and feelings is conspicuous. The neurobiological basis of autism is unknown, but histopathological and biochemical findings suggest a diffuse disorder of neuronal development, most severe in the fronto-temporal cortex, some limbic structures and in the cerebellum. At a biochemical level, abnormalities in serotonin and other neurotransmitters have been reported.


REFERENCES

  1. 1. Rapin I. Autism, current concepts.N Engl Jour Med 1997;337:97-104.

  2. 2. DeMyer W, DeMyer M. Infantile autism. Neurologic Clinics 1984;2:139-153.

  3. 3. Calderón GR, Vallejo MD, Santillán FA, Rodríguez CO, et al. Autismo infantil. I Estudio clínico de 27 niños. Bol Med Hos Infant Mex 1988;45:12-17.

  4. 4. Rapin I. Autistic children: Diagnosis and clinical features. Pediatrics 1991;87(Suppl):751-760.

  5. 5. Rapin I. Katzman R. Neurobiology of Autism. Ann Neurol 1998;43;7-14.

  6. 6. Howlin P. Prognosis in autism: do specialist treatments affect long-term outcome? European Child & Adolescent Psychiatry 1997;6:55-72.

  7. 7. Herbert MR, Gordon JH, Kristen TA, Ziegier DA, Makris N, et al. Abnormal Asymmetry in Language Association Cortex in Autism. Ann Neurol 2002;52:588-596.

  8. 8. Calderón GR, Santillán FA, Rodríguez CO, Pomar SA, Gutierrez TM, et al. Autismo infantil. II. Estudio de Lenguaje en 27 niños. Bol Med Hos Infant Mex 1988;45:79-83.

  9. 9. Mazzocco MM. Kates WR, Baumgarner TL, Freund LS, et al. Autistic behavior among girls with fragile X syndrome. J Autism-Dev Disord. 1997;27:415-435.

  10. Shannon M, Graef JW. Lead intoxication in children with pervasive developmental disorders. J. Toxicol Clin Toxicol 1996;34:177-181.

  11. Rutter M, Bailey A, Bolton P, Le-Couteur A. Autism and known medical conditions: myth and substance. J Child Psychol Psychiatry. 1994;35;311-322.

  12. Wakefield AJ, Murch SH, Anthony A, Linneli J, Casson DM, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorders in children. Lancet 1998;351:637-641.

  13. Rapin I, Dunn M. Language disorders in children with autism. Semin Pediatr Neurol 1997;4:86-92.

  14. Tonge BJ, Dissanayake C, Brereton AV. Autism:fifty years on from Kanner. J Paediatr Child Health 1994;30:102-107.

  15. Minshew NJ, Goldstein G, Siegel DJ. Neuropsychologic functioning in profile of a complex information processing disorder. J Int Neuropsyxhol Soc 1997;3:303-316.

  16. Filipek PA, Accardo PJ, Ashwal MD, Baranek GT, Cook EH, et al. Practice screening and diagnosis of autism. Report of the quality standards subcommittee of the American Academy of Neurology and the Child Neurology Society. Neurology 2000;55:468-479.

  17. O’Neili M, Jones RS. Sensory-perceptual abnormalities in autism: a case for more research? J Autism Dev Disord 1997;27:283-293.

  18. Pierce K, Glad KS, Schreibman L. Social perception in children with autism: an attentional deficit? J Autism Dev Disord 1997;27:265-282.

  19. Oisson I, Steffenburg S, Giliberg C. Epilepsy in autism and autistic-like conditions. A population based study. Arch Neurol 1988;45:666-668.

  20. Richdale A. Sleep problems in autism: prevalence, cause, and intervention. Development Medicine & child neurology 1999;41:60-66.

  21. Rapin I. Autism in search of a home in the brain. Editorial, Neurology 1999;52:902-904.

  22. De Long, R. Autism. New data suggest new hypothesis. Neurology 1999;52:911-916.

  23. Bolton PF, Griffiths PD. Association of tuberous sclerosis of temporal lobes with autism and atypical autism. Lancet 1997;349:392-395.

  24. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, et al. Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 2001;57:1269-1277.

  25. Calderón RG, Treviño WJ, Calderón SA. Autismo en la esclerosis tuberosa. Gac Med de México 1994;130:374-379.

  26. Lauritsen MB, Ewald H. The genetics of autism. Acta Psychiatr Scand 2001;103:411-427.

  27. Bauman M, Kemper TL. Histoanatomic observations of the brain in early infantile autism. Neurology 1985;35:866-874.

  28. Bailey A, Luthert P, Dean A, Hardin B, Janota, et al. A clinicopathological study of autism. BRAIN 1998;121:889-905.

  29. Courchesne E, Mulier RA, Saitoh O. Brain weight in autism: normal in the majority of cases, megalencephalic in rare cases. Neurology 1999;52:1057-1059.

  30. Weidenheim KM. NeuropatologÍa del autismo. Neurociencia 2001;2:133-137.

  31. Casanova MF, Buxhoeveden DP, Switala AE, Roy E. Minicolumnar pathology in autism. Neurology 2002;58:428-432.

  32. Purcel AE, Jeon OH, Zimmerman AW, Blue ME, Pevsner J. Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology 57: 1618-28, 2001.

  33. Coruchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, et al. Unusual brain growth patterns in early life in patients with autistic disorder. An MRI study. Neurology 2001;57:245-254.

  34. Minshew NJ, Luna B, Sweeney JA. Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology 199952:917-922.

  35. 35 Asociación Psiquiátrica Americana, Manual de diagnóstico y estadística de los trastornos mentales (DSM-IV-TR). Masson, SA, Barcelona, 2002, pp 5358.

  36. Rapin I. Appropriate investigations for clinical care versus research in children with autism. Brain & Development 1999;21:152-156.

  37. 37 Damasio H, Maurer R, Damasio AR, Chui H. Computed tomographic scan findings in patients with autistic behavior. Arch Neurol 1980;37:504-510.

  38. Courchesne E, Yeung-Courchesne R, Pres GA, Hesselink JR, Jernigan TL. Hypoplasia of cerebellar vermal lobules VI and VII in autism. N Engl J Med 1988;318:1349-1354.

  39. Piven J, Arndt S, Bailey J, Havercamp S, Andreasen N, et al. An MRI study of brain size in autism. Am J Psychiatry 1995;152:1145-1149.

  40. Piven J, Saliba K, Bailey J, Arndt S. An MRI study of autism: The cerebellum revisited. Neurology 1997;49:546-551.

  41. Sánchez LE, Campbeli M, Cueva JE, Armenteros JL, Adams PB. A pilot study of chlomipramine in young autistic children. J Am Acad Child Adolesc Psychiatry 1996;35:537-544.

  42. Ruggieri VL. An approach to the pharmacological treatment of autism. Rev Neurol 1996;24:1451-1455.

  43. Chabrol H, Bonnet D, Roge B. Psychopharmacology of autism. Encephale. 1996;22:197-203.

  44. Horrigan JP, Barnhili LJ. Risperidone and explosive aggressive autism. J Autism Dev Disord 1997;27:313-23.

  45. Ernst M, Devi I, Silva RR, Gonzalez NM, Smali AM, et al. Plasma beta-endorphin levels, naltrexone and haloperidol in autistic children. Psychopharmacol Bull 1993;29:221-227.

  46. Sher L. Autistic disorder and the endogenous opioid system. Med Hypotheses 1997;48:413-14.

  47. Willemsen, SSH, Buitelaar, JK, van-Engeland, H. The effects of chronic naltroxone treatment in young autistic children: a double-blind placebo controlled crossover study. Biol Psychiatry 1996;39:1023-1031.

  48. Campbell M, Anderson LT, Smali AM, Adams P, Gonzalez NM et al. Naltrexone in autistic children: behavioral symptoms and attentional learning. J Am Acad Child Adolesc Psychiatry 1993;32:1283-1291.

  49. Naffah, MMG, Rosenber, R, Fernandez MJ, Draque CM, Silvestrini W, et al. FERUM serotonin levels of normal and autistic children. Braz J Med Biol Res 1993;26:309-317.

  50. Mc Dougie CJ, Naylor ST, Cohen DJ, Voikmar FR, Heninger GR, et al. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 1996;53:1001-1008.

  51. Hellings JA, Keliey LA, Gabrielli WF, Kilgore E , Shah P. Sertraline response in adults with mental retardation and autistic disorder. J Clin Psychiatry 1996;57:333-336.

  52. Steingard RJ, Zimnitzky B, DeMaso DR, Bauman ML, Bucci JP. Sertraline treatment of transition associated anxiety and agitation in children with autistic disorder. J Child Adolesc Psychopharmacol 1997;7:9-15.

  53. McCormick LH. Treatment with buspirone in a patient with autism. Arch Fam Med 1997;6:368-370.




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