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2014, Number 1

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Revista Habanera de Ciencias Médicas 2014; 13 (1)

Post-surgical treatment mortality and survival, in patients treated with radical hysterectomy with cancer of the cervix

Bobadilla MA, Esperón NR, Mora DIB, Silveira PJM, Linchenat LA, Montero LJF

Language: Spanish
References: 30
Page: 36-45
PDF size: 75.82 Kb.


ABSTRACT

Introduction: the cervical cancer is still a health problem in women worldwide, and it remains a one of the leading cause of cancer-related death for.
Objective: describe the post-surgical treatment mortality and survival in patients treated with radical hysterectomy, with clinical state Ia2 and Ib1 cancer of the cervix diagnosis.
Material and Method: there for a retrospective and descriptive study was conducted, that includes 27 patients with this type of neoplasms, stages Ia2 and Ib1 treated with radical hysterectomy at the Service of Gynecology of the National Institute of Oncology and Radiobiology of La Habana, from 2002 to 2007. The results of the surgical procedure were described, and the disease free interval and the overall survival were determined by the Kaplan-Meier method.
Results: 92.6 % of the studied patients corresponded to stage Ib1. There were no operative mortality or medical morbidity and the surgical morbidity affected 4 patients. A predominance of sepsis was observed. The disease recurred in 3.7 % of the total cases. It was obtained a disease free interval global of 96.3 % and a total survival of 100 %.
Conclusions: radical hysterectomy is a safe treatment for cervix cancer in our environment.


REFERENCES

  1. Berek Jonathan S. Novak's Gynecology, 14th Edition. Philadelphia, United States of America: Lippincott Williams & Wilkins; 2007.

  2. Kantarjian Hagop M, Wolff Robert A, Koller Charles A. The MD Anderson Manual of Medical Oncology. Part VIII. Gynecologic Malignancies. Chapter 24.Tumors of the Uterine Cervix. United States of America: The McGraw-Hill Companies; 2007.

  3. Rock JA, Jones Howard W. Te Linde's Operative Gynecology, 10th Edition. Chapter 47.Cáncer of the cervix. Philadelphia, United States of America: Lippincott Williams & Wilkins; 2008.

  4. Instituto Nacional del Cáncer de EE.UU. Cáncer de Cuello Uterino: Tratamiento (PDQ®). (Consultado 31 de mayo 2013). Disponible en: http://cáncer.gov/ espanol/pdq/tratamiento/cuellouterino/HealthProfessional

  5. Silveira Pablos M, Linchenat Lambert A, Aguiar Vela de Oro O, Bosque Diego OJ, Montero Jorge F, et al. Guías de Diagnóstico y Tratamiento en Oncología para el Cáncer de Cuello Uterino. La Habana: Instituto de Oncología y Radiobiología; 2012.

  6. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Cervical Cancer 2009; v.1 (Consultado August 25, 2009). Disponible en: http://www.nccn.org/professionals/physician_gls/PDF/cervical.pdf.

  7. Bansal N, Herzog TJ, Shaw RE, Burke WM, Deutsch I, Wright JD. Primary therapy for early-stage cervical cancer: radical hysterectomy vs radiation. Am J Obstet Gynecol. Nov, 2009; 201(5):485.

  8. Hacker NF. Cervical Cancer. In: Berek JS, Hacker NF. Practical Gynecologic Oncology. 4th ed. Philadelphia, United States of America: Lippincott Williams & Wilkins; 2005, p.337 - 396.

  9. Undurraga M, Loubeyre P, Dubuisson JB, Schneider D, Petignat P. Early-stage cervical cancer: is surgery better than radiotherapy? Expert Rev Anticáncer Ther. 2010 Mar; 10(3):451-60.

  10. The new FIGO staging system for cancers of the vulva, cervix, endometrium and sarcomas. Gynecology Oncology. October 12, 2009; 115: 325-328.

  11. Bosque Diego O, Arrebola Suárez JA, Iruretagoyena Batista D, Aguiar Vela de Oro O, Silveira Pablo M, Díaz Ortega I, et al. Histerectomía Radical en el cáncer cérvico-uterino en estadio Ia2 y Ib1. Rev Cubana Oncol. 1999;15(1):19-25.

  12. Rosabal Infante F, Morales González RA, Rosabal Olivé F. Operación de Wertheim-Meigs en el tratamiento del cáncer de cuello uterino en estadio I. Rev Cubana ObstetGinecol. 2004; 30(2).

  13. Nápoles Méndez D, García Goderich AG, Simonó Bell M. Resultados de la operación de Wertheim-Meigs. Análisis de algunas variables. Rev Cubana ObstetGinecol.1999;25(1):10-3.

  14. Howley PM. Role of the human papillomaviruses in human cancer. Cancer Res. Sep. 1991; 51(18 Suppl):5019s-5022s.

  15. Arends MJ, Wyllie AH, Bird CC. Papillomaviruses and human cancer. HumPathol. Jul, 1990; 21(7):686-98.

  16. Clavel C, Masure M, Bory JP, et al. Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women. Br J Cancer. Jun 15, 2001;84(12):1616-23.

  17. Aguilar Fabré K, Ríos Hernández MA, Hernández Menéndez M, Aguilar Vela de Oro FO, Silveira Pablos M, et al. Papiloma viral humano y cáncer de cuello uterino. Rev Cubana ObstetGinecol [revista en la Internet]. 2008 Abr; 34(1). [Consultado Dic 1, 2010]. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext &pid=S0138-600X2008000100003&lng=es.

  18. Rylander E, Ruusuvaara L, Almstromer MW, Evander M, Wadell G. The abscense of vaginal human papillomavirus 16 DNA in women who have not experienced sexual intercourse. Obstet Gynecol. 1994; 83(5):735-7

  19. Autier P, Coibion M, Huet F, Grivegnee AR. Transformation zone location and intraepithelial neoplasia of the cervix uteri. Br J Cáncer. 1996; 74:488-90.

  20. U.S. Preventive Services Task Force. Screening for Cervical Cáncer. AHRQ: Agency for Healthcare Research and Quality. (Consultado August 25, 2009). Disponible en: http://www.ahrq.gov/clinic/USpstf/uspscerv.htm.

  21. Smith RA, Cokkinides V, Brawley OW. Cancer screening in the United States, 2009: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. Jan-Feb 2009; 59(1):27-41.

  22. ACOG Practice Bulletin number 109, December 2009. Cervical cytology screening. Obstet Gynecol. Dec, 2009; 114(6):1409-1420.

  23. Programa Nacional de Diagnóstico Precoz del Cáncer Cérvico Uterino de Cuba. La Habana: MINSAP; 2001.

  24. Jori S, Carter MD. Radical Hysterectomy. Medscape Medical Reference [serial online]. (Consultado Jan 16, 2013). Disponible en:http://emedicine.medscape.com/ article/270723-overview

  25. Fanfani F, Fagotti A, Ferrandina G, Raspagliesi F, Ditto A, Cerrotta AM, et al. Neoadjuvant chemoradiation followed by radical hysterectomy in FIGO Stage IIIB cervical cancer: feasibility, complications, and clinical outcome. Int J GynecolCancer. Aug, 2009; 19(6):1119-24.

  26. Barakat RR, Markman M, Randall ME. Principles and Practice of Gynecologic Oncology. 5th ed. Philadelphia, United States of America: Lippincott Williams & Wilkins; 2009, p.623-682.

  27. Pérez Echemendía M. Ginecología Oncológica Pelviana. Cap 4. Cáncer cervicouterino. La Habana: Ed ECIMED; 2006, p.79-133.

  28. Monk, BJ, Tewari, KS. Invasive cervical cáncer. In: Clinical Gynecologic Oncology, 7th ed. DiSaia, PJ, Creasman, WT (Eds). Philadelphia: Mosby Elsevier; 2007, p. 81.

  29. Fregnani JHTG, Soares FA, Novik PR, Lopes A, Latorre MRDO. Fatores de risco não habituais para metástase linfonodal no câncer do colo do útero [Unusual risk factors for lymph node metastasis in cáncer of the uterine cervix]. RevAssocMedBras. 2007; 53(4):338-43.

  30. Tavares M, et al. Prevalence of prognostic factors for cancer of the uterine cervix after radical hysterectomy. Sao Paulo Med. J. 2009;127(3): 145-149.




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