2014, Number 1
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Rev Mex Anest 2014; 37 (1)
Utility of dexmedetomidine in various contexts in modern medicine
Carrillo-Torres O, Pliego-Sánchez MG, Gallegos-Allier MM, Santacruz-Martínez LC
Language: Spanish
References: 69
Page: 27-34
PDF size: 297.56 Kb.
ABSTRACT
In recent years, drugs have been developed to achieve adequate sedation and analgesia in patients before, during and after medical procedures. Among these is dexmedetomidine, a highly selective alpha-2 drug that achieves, in adequate dosage, analgesia, sedation and sympatholysis without major adverse effects. This drug has been used extensively in intensive care, for which it was designed, but also for various anesthesiological procedures in general and regional anesthesia, as well as superficial and deep sedation in adults and in pediatric populations. In this review we will cover the generalities of dexmedetomidine and its uses in different specialties to date.
REFERENCES
Klimscha W, Chiari A, Krafft P, Plattner O, Taslimi R, Mayer N, et al. Hemodynamic and analgesic effects of clonidine added repetitively to continuous epidural and spinal blocks. Anesth Analg. 1995;80:322-327.
Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Zbinden AM. Epidural epinephrine and clonidine: segmental analgesia and effects on different pain modalities. Anesthesiology. 1997;87:785-794.
Haselman MA. Dexmedetomidine: a useful adjunct to consider in some high-risk situation. AANA J. 2008;76:335-339.
Nacif-Cohelo C, Correa-Sales C, Chang LL, Maze M. Perturbation of ion channel conductance alters the hypnotic response to the alfa 2-adrenergic agonist dexmedetomidine in the locus ceruleus of the rat. Anesthesiology. 1994;81:1527-1534.
Nazarian A, Christianson CA, Hua XY, Yaksh TL. Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by 2A-adrenoceptors. Br J Pharmacol. 2008;155:1117-1126.
Sánchez E, Chávez O, Hernández D. Dexmedetomidina en anestesia pediátrica. Anestesia en México. 2006;Supl 1:112-119.
Savola J, Virtanen R. Central [Alpha] 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur J Pharmacol. 1991;195:193-199.
Guo TZ, Jiang J, Buttermann A, Maze M. Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology. 1996;84:873-881.
Tverskoy M, Oz Y, Isakson A, Finger J, Bradley EL, Kissin I. Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. Anesth Analg. 1994;78:205-209.
Coursin DB, Maccioli GA. Dexmedetomidine. Curr Opin Crit Care. 2001;7(4):221-226.
Paris A, Tonner PH. Dexmedetomidine in anaesthesia. Curr Opin Anaesthesiol. 2005;18:412-418.
Perdomo G. Alfa 2 agonistas en anestesia pediátrica. Italian Internet Journal of pediatric and neonatal anesthesia [Internet]. 2008;6(1). Disponible en: http://www.anestesiarianimazione.com
Petroz GC, Sikich N, James M, van Dyk H, Shafer SL, Lerman J. A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology. 2006;105:1098-1110.
Hall J, Uhrich TD, Barney JA. Sedative, amnestic and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg. 2000;90:699-705.
Talke P, Richardson CA, Scheinin M, Fisher DM. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg. 1997;85:1136-1142.
Ebert T, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93:382-394.
Dyck J, Maze M, Haack C, Vuorilehto LM, Shafer SL. Computer-controler infusion of intravenous dexmedetomidine hydrochplide in adult human volunteer. Anesthesiology. 1993;78:821-828.
Scheinin H, Karhurvaara S, Olkkola KT, Kallio A, Anttila M, Vuorilehto L, et al. Pharmacodynamics and pharmacokinetics of intramuscular dexmedetomidine. Clin Pharmacol Ther. 1992;52:537-546.
Rosen D, Daume J. Short duration large dose dexmedetomidine in a pediatric patient during procedural sedation. Anesth Analg. 2006;103:68-69.
Cooper L, Samson R, Gallagher C. Dexmedetomidine provides excellent sedation for elective, awake fiberoptic intubation. Anesthesiology. 2005;103:A1449.
Hofer RE, Sprung J, Sarr MG, Wedel GJ. Anesthesia for a patient with morbid obesity using dexmedetomidine without narcotics. Can J Anaesth. 2005;52:176-180.
Tobias JD. Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med. 2007;8:115-131.
Shukry M, Kennedy K. Dexmedetomidine as a total intravenous anesthetic in infants. Paediatr Anaesth. 2007;17:581-583.
Wienbroun A, Ben AR. Dextromethorphan and dexmedetomidine, new agents for the control of perioperative pain. Eur J Surg. 2001;167:563-569.
Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: a meta-analysis. Am J Med. 2003;114:742-752.
Venn RM, Grounds RM. Comparison between dexmedetomidine and propofol for sedation in the intensive care unit: patient and clinician perceptions. Br J Anaesth. 2001;87:684-690.
Ibacache M, Pedrozo Z, Fernández C, Sánchez G, Lavandero S. Infarto perioperatorio en cirugía no-cardíaca y dexmedetomidina. Rev Chil Cardiol. 2010;29:100-116.
Ickeringill M, Shehabi Y, Adamson H. Dexmedetomidine infusion without loading dose in surgical patients requiring mechanical ventilation: haemodynamic effects and efficacy. Anaesth Intensive Care. 2004;32:741-745.
Chrysostomou C, Shiderly D, Berry D. Dexmedetomidine, a novel agent for the acute treatment of supraventricular tachyarrhythmias after pediatric cardiac surgery. Crit Care Med. 2007;8:A2.
Al-Zaben K, Qudaisat IY, Al-Ghanem SM, Massad IM, Al-Mustafa MM, Al-Oweidi AS, et al. Intraoperative administration of dexmedetomidine reduces the analgesic requirements for children undergoing hypospadius surgery. Eur J Anaesthesiol. 2010;27:247-252.
Alvaez I, Gallerdo L, Martínez E. Dexmedetomidina oral como medicación preanestésica en pacientes pediátricos. Comparación entre dosis y efectos clínicos. An Med (Mex). 2006;51:113-119.
Hammer G, Drover DR, Cao H, Jackson E, Williams GD, Ramamoorthy C, et al. The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg. 2008;106:79-86.
Penttilä J, Helminen A, Anttila M, Hinkka S, Scheinin H. Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects. Can J Physiol Pharmacol. 2004;82:359-362.
Massad I, Mohsen WA, Basha AS, Al-Zaben KR, Al-Mustafa MM, Alghanem SM. A balanced anesthesia with dexmedetomidine decreases postoperative nausea and vomiting after laparoscopic surgery. Saudi Med J. 2009;30:1537-1541.
Frost EA, Booij LH. Anesthesia in the patient for awake craniotomy. Curr Opin Anaesthesiol. 2007;20:331-333.
Rozet I. Anesthesia for functional neurosurgery: the role of dexmedetomidine. Curr Opin Anaesthesiol. 2008;21:537-543.
Tanskanen PE, Kyttä JV, Randell TT. Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomized and placebo-controlled study. Br J Anaesth. 2006;97:658-665.
Sanders R, Xu J, Shu Y, Januszewski A, Halder S, Sun P, et al. Dexmedetomidine attenuates isofluorane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 2009;110:1077-1085.
Tobias JD, Berkenbosch JW. Sedation during mechanical ventilation in infants and children: dexmedetomedine versus midazolam. South Med J. 2004;97:451-455.
Kobayashi A, Okuda T, Kotani T, Oda Y. Efficacy of dexmedetomidine for controlling delirium in intensive care unit patients. Masui. 2007;56:1155-1160.
Yuen V, Irwin M, Hui T, Yuen M. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. Anesth Analg. 2007;105:374-380.
Bagatini A, Gomes CR, Masella MZ, Rezer G. Dexmedetomidine. Pharmacology and clinical application. Rev Bras Anestesiol. 2002;52:606-617.
Carollo D, Nossaman B, Radhyani U. Dexmedetomidine: a review of clinical applications. Curr Opin Anesth. 2008;21: 457-461.
Kamal K, Soliman D, Zakaria D. Oral dexmedetomidina versus oral midazolam as premedication in children. Shams Journal of Anesthesiology. 2008;45:109-112.
Koroglu A, Demirbilek S, Teksan H. Sedative, haemodynamic and respiratory effects of dexmedetomidine in children undergoing magnetic resonance imaging examination: preliminary results. BJA. 2005;13:101-105.
Mason K, Zgleszewki S, Prescilla R, Fontaine P, Zurakowski D. Dexmedetomidine for pediatric sedation for computed tomography imaging studies. Pediatric Anesthesia. 2008:18:393-402.
Berkenbosch J, Wankum P, Tobias J. Prospective evaluation of dexmedetomidine for noninvasive procedural sedation in children. Pediatric care medicine. 2005;6:435-439.
Jaakola ML. Dexmedetomidine premedication before intravenous regional anesthesia in minor outpatient hand surgery. J Clin Anesth. 1994;6:204-211.
Panzer O, Moitra V, Sladen RN. Pharmacology of sedative-analgesic agents: dexmedetomidine, remifentanil, ketamine, volatile anesthetics, and the role of peripheral mu antagonists. Crit Care Clin. 2002;25:451-469.
Unlugenc H, Gunduz M, Guler T, Yagmur O, Isik G. The effect of pre-anaesthetic administration of intravenous dexmedetomidine on postoperative pain in patients receiving patient controlled morphine. Eur J Anaesthesiol. 2005;22:386-391.
Lin TF, Yeh YC, Lin FS, Wang YP, Lin DJ, Sun WZ, et al. Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia. Br J Anaesth. 2009;102:117-122.
Sturaitis MK, Kroin JS, Swamidoss CP. Effects of intraoperative dexmedetomidine infusion on hemodynamic stability during brain tumor resection. Anesthesiology. 2002;97:A310.
Mato M, Pérez M, Otero J, Torres ML. Dexmedetomidina, un fármaco prometedor. Rev Esp Anestesiol Reanim. 2002;49:407-420.
Tufanogullari B, White PF, Peixoto MP. Dexmedetomidine infusion during laparoscopic bariatric surgery. Anesthetic Pharmacology. 2008;106:1741-1748.
Triltsch AE, Welte M, von Homeyer P. Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Crit Care Med. 2002;30:1007-1014.
Brummett C, Trivedi KA, Dubovoy AV, Berland DW. Dexmedetomidine as a novel therapeutic for postoperative pain in a patient treated with buprenorphine. J Opioid Manag. 2009;5:175-179.
Coyne P, Wozencraft CP, Roberts SB, Barton B, Smith TJ. Dexmedetomidine: exploring its potential role and dosing guideline for its use in intractable pain in the palliative care setting. J Pain Palliat Care Pharmacother. 2010;24:384-386.
Aantaa R, Jaakola ML, Kallio A, Kanto J. Reduction of the minimun alveolar concentration of isofluorane by dexmedetomidine. Anesthesiology. 1997;86:1055-1060.
Aho M, Erkola O, Kallio A. Dexmedetomidine infusion for maintenance of anesthesia in patients undergoing abdominal hysterectomy. Anesth Analg. 1992;75:940-946.
Grosu I, Lavand’homme P. Use of dexmedetomidine for pain control. F 1000 Med Rep. 2010;2:90.
Tan JA, Ho K. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis. Intensive Care Med. 2010;36:926-939.
Pandharipande PP, Pun BT, Herr DL. Effect of sedation with dexmedetomidine versus lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644-2653.
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, et al. Dexmedetomidine versus midazolam for sedation of critically ill patients. JAMA. 2009;301:489-499.
Ruokonen E, Parviainen I, Jakob SM, Nunes S, Kaukonen M, Shepherd ST, et al. Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation. Intensive Care Medicine. 2009;35:282-290.
Maldonado JR, Wysong A, van der Starre PJ, Block P, Miller C, Reitz BA. Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 2009;50:206-217.
Reade MC, O’Sullivan K, Bates S, Goldsmith D, Ainslie WR, Bellomo R. Dexmedetomidine versus haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Critical Care. 2009;13:R75.
Roberts S, Wozencraft CP, Coyne PJ, Smith TJ. Dexmedetomidine as an adjuvant analgesic for intractable cancer pain. J Palliat Med. 2011;14:371-373.
Hayashid K, Eisenach JC. Spinal alfa 2 adrenoreceptor-mediated analgesia in neurophatic pain reflex brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology. 2010;113:406-412.
Jackson K, Wohlt P, Fine PG. Dexmedetomidine. A novel analgesic with palliative medicine potential. J Pain Palliat Care Pharmacother. 2006;20:23-27.