O’Farrill-Romanillos PM, Galindo-Pacheco LV, Amaya-Mejía AS, Campos-Romero FH, Mendoza-Reyna LD, Pérez-Rocha F, Segura-Méndez NH

Language: Spanish
References: 13
Page: 94-97
PDF size: 56.03 Kb.

ABSTRACT

Background: common variable immunodefi ciency is a primary immunodefi ciency, in which from 70 to 80 % of patients have tumors and 25 % of cases are associated with autoimmune diseases. Common variable immunodefi ciency patients have a higher incidence of neoplasms, with a risk 12-18 times higher than the general population. There are few cases of common variable immunodefi ciency patients with leukemia.
Clinical case: female of 36 years old, with left upper quadrant pain, early satiety, weight loss of 8 kg in three months and splenomegaly. The complete blood count showed: leukocytosis 206 000/µL, with 8 % blasts, platelets 530 000/µL and hemoglobin 8 mg/dL. Abdominal ultrasound: 19X12 cm splenomegaly. Karyotype BCR/ABL IS 64.20 %, 100 % Philadelphia chromosome. The diagnosis was of chronic myeloid leukemia. Given the presence of recurrent respiratory tract infection, frequent diarrheas and reduced concentrations of IgG, IgM and IgA, common variable immunodefi ciency was diagnosed and human immunoglobulin was used successfully.
Conclusions: the association between chronic myeloid leukemia and common variable immunodeffi ciency is unusual. Given the high frequency of hematological neoplasm in common variable immunodefi - ciency patients, we suggest that hematological patients with repeated infections and decreased concentrations of immunoglobulin be referred to an immunological evaluation.

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