2013, Number 4
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Revista Habanera de Ciencias Médicas 2013; 12 (4)
Varicella Infection during Pregnancy. A Sixteen-Year Study
Llanusa RC, Nodarse RA, Sánchez LR, Peña AR, Carrillo BL, Fajardo PY
Language: Spanish
References: 23
Page: 571-578
PDF size: 46.00 Kb.
ABSTRACT
Introduction: congenital varicella syndrome affects about 2% of children of mothers with primary infection of chickenpox. There is consensus on this pregnant ultrasound monitoring, recommending the assessment of fetal growth, head circumference and long- bone measurements, assessment of brain structures, characteristics of the liver, and amniotic fluid.
Objective: to evaluate the effects on fetus of maternal infection with varicella.
Material and Methods: a sixteen-year retrospective study was conducted including patients affected by chickenpox at any time of their pregnancy; they were assisted at genetic service at Ramón González Coro Hospital. Data from 133 patients evaluated were collected. The course of pregnancy and newborn could be known in 97 of them.
Results: out of the total of cases studied, postnatal outcomes were obtained in 95; fetal losses occurred in 2, one of them was described as congenital varicella syndrome. A visual deficit in one eye was described in one case during follow-up. Fetal varicella infection was found in about 2% of cases considering the latter referred.
Conclusions: fetal infection had a similar pattern to that reported in the literature regarding clinical and percentages. Pregnant women suffering from chickenpox infection need for better antenatal care, to ensure a good pregnancy outcome.
REFERENCES
Ghidini A, Lynch L. Management strategies for congenital infections. Mt Sinai J Med. 1994 Oct;61(5):376-88.
Smith C, Arvin A. Varicella in the fetus and newborn. Seminars in Fetal & Neonatal Medicine. 2009; 14:209-217.
Lamont RF, Sobel JD, Carrington D, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Romero R. Varicella-zoster virus (chickenpox) infection in pregnancy. BJOG. 2011; 118(10):1155-62.
Cohen A, Moschopoulos P, Stiehm RE, Koren G. Congenital varicella syndrome: the evidence for secondary prevention with varicella-zoster immune globulin. CMAJ. 2011; 183(2):204-8.
Verstraelen H, Vanzieleghem B, Defoort P, Vanhaesebrouck P, Temmerman M. Prenatal ultrasound and magnetic resonance imaging in fetal varicella syndrome: correlation with pathology findings. Prenat Diagn. 2003; 23: 705-709.
Daley AJ, Thorpe S, Garland SM. Review Varicella and the pregnant woman: prevention and management. Aust N Z J Obstet Gynaecol. 2008 Feb; 48(1):26-33.
Heuchan A, Isaacs D. The management of varicella-zoster virus exposure and infection in pregnancy and the newborn period. MJA. 2001; 174: 288-292.
Sauerbrei A, Wutzler P. Herpes simplex and varicella-zoster virus Infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: Varicella-zoster virus infections. Med Microbiol Immunol. 2007; 196(2):95-102.
Boumahni B, Kauffmann E, Laffitte A, Randrianaivo H, Fourmaintraux. Congenital varicella: limits of prenatal diagnosis A. Arch Pediatr. 2005 Sep;12(9):1361-3.
Weisz B, Book M, Lipitz S, Katorza E, Achiron R, Grossman Z, Shrim A. Fetal outcome and amniocentesis results in pregnancies complicated by varicella infection. J Obstet Gynaecol Can. 2011 Jul;33(7):720-4.
Pupco A, Bozzo P, Koren G. Herpes zoster during pregnancy Fam Physician. 2011 October; 57(10):1133.
Salas NR, Silva FC. Síndrome de varicela fetal. Rev. chil. pediatr. [revista en Internet]. jun. 2003;74(3): 299-303. [Citado 20 Noviembre 2005]. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062003000300008&lng=es&nrm=iso
Mandelbrot L. Fetal varicella-diagnosis, management, and outcome. Prenat. Diagn. 2012; 32 (6): 511-518.
Shrim A, Koren G, Yudin MH, Farine D. Review Management of varicella infection (chickenpox) in pregnancy. Maternal Fetal Medicine Committee. J Obstet Gynaecol Can. 2012 Mar; 34(3):287-92.
Martínez MJ. Infecciones virales y exantemas no tradicionales. Rev. chil. pediatr. [revista en Internet]. jun. 2005;76(3): 309-315.[Citado 20 Noviembre 2005]. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062005000300012&lng=es&nrm=iso
Wittek M, Doerr HW, Allwinn R. Varicella and herpes zoster. Part 2: therapy and prevention. Med Klin. 2010;105(6):399-403.
Gnann JW Jr. Varicella-zoster virus: Prevention through vaccination. Clin Obstet Gynecol. 2012; 55(2):560-70
Cohen A, Moschopoulos P, Stiehm R, Koren Congenital varicella syndrome: the evidence for secondary prevention with varicella-zoster immune globulin. G. CMAJ. 2011; 183(2): 204-208.
Alfonsi V, Montomoli E, Manini I, Alberini I, Gentile C, Rota MC, Ciofi degli Atti ML Susceptibility to varicella in childbearing age women, Central Italy: is there a need for vaccinating this population group? Vaccine. 2007 Aug 10; 25(32):6086-8.
Mirlesse V, Duguy N, Cynober E, Francois Magny J, Daffos F. Alphafoetoprotein and acetylcholinesterase in amniotic fluid as a factor suggesting fetal skin and nerve lesions in a case of congenital varicella syndrome. Prenat Diagn. 2004 Jul;24 (7):498-500.
Mirlesse V, Sole Y, Jacquemard F, Delhommeau F, Daffos F Persistent maternal viremia after varicella infection during pregnancy as a possible cause of false positive prenatal diagnosis of fetal infection on amniotic fluid. BJOG. 2004 Aug: 111(8):885-7.
Tongsong T, Srisupundit K, Traisrisilp K. Prenatal sonographic diagnosis of congenital varicella syndrome. J Clin Ultrasound. 2012; 40(3):176-8.
Pastuszak AL, Levy M, Schick B, Zuber C, Feldkamp M, Gladstone J, Bar-Levy F, Jackson E, Donnenfeld A, Meschino W, Koren G. Outcome after Maternal Varicella Infection in the First 20 Weeks of Pregnancy. N Engl J Med. 1994; 330(13): 901-5.