medigraphic.com
ISSN 1561-3046 (Electronic)

2013, Number 4

<< Back Next >>

Rev Cub Med Mil 2013; 42 (4)

Neuropsychological, extrapyramidal and neuroimaging alterations observed in frontotemporal dementia

Cantero CD, González TR, García LY, Arrieta HT, García SS, Méndez MFM

Language: Spanish
References: 15
Page: 490-494
PDF size: 35.08 Kb.


ABSTRACT

Frontotemporal dementias are neurodegenerative diseases that fundamentally compromise the frontal and temporal lobes and cause alterations in behavior and language. They are the third cause of degenerative dementia after Alzheimer's disease and Lewy body dementias. Here are two cases which firstly began with bilateral akinetic rigid syndrome without posture disorders, dysexecutive syndrome and altered higher cognitive functions such as language. The magnetic resonance imaging detected atrophy of predominance in the frontal and temporal lobes. The diagnosis was frontotemporal dementia with predominant dorsolateral and mesial frontal effects. In comparison with other types of dementia, the frontotemporal one is considered to be a difficult-to-diagnose disorder by clinicians. It is only possible to identify it through biopsy and/or necropsy.


REFERENCES

  1. Snowden JS, Neary D, Mann D. Frontotemporal lobar degeneration: frontotemporal dementia, progressive aphasia, semantic dementia. London: Churchill Livingstone; 1996.

  2. Pascal R, Esslimani SM, Mäkelä S, Gustafsson JÅ, Baldet P, Rochefort H. Decreased Expression of Estrogen Receptor  Protein in Proliferative Preinvasive Mammary Tumors. Cancer Res [Internet] 2001 [cited 2008 Oct 3]61;2537. Available from: http://cancerres.aacrjournals.org/content/61/6/2537.full

  3. Graham A, Hodges JR. Frontotemporal dementia. Psychiatry. 2008;7:24-8.

  4. Johnson J, Diehl J, Mendez M, Neuhaus J, Shapira J, Forman M, et al. Frontotemporal lobar degeneration. Arch Neurol. 2005;62:925-30.

  5. Vossel KA, Miller BL. New approaches to the treatment of frontotemporal lobar degeneration. Curr Opin Neurol. 2008;21:708-16.

  6. Josephs KA. Frontotemporal dementia and related disorders: deciphering the enigma. Ann Neurol. 2008;64:4-14.

  7. Peelle JE, Grossman M. Language processing in frontotemporal dementia: a brief review. Lang Ling Compass. 2008;2:18-23.

  8. Gorno-Tempini M L, Brambati S M, Ginex B, Ohar J, Marcone A, Perani D, et al. The logopenic/phonological variant of primary progressive aphasia. Neurology. 2008;71:1227-3411.

  9. Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, et al. Behavioral features in sementic dementia vs other forms of progressive Aphasia. Neurology 2006;67:1752-6.

  10. Mesulam MM. Primary progressive aphasia. Ann Neurol. 2001;49:425-32.

  11. Foulds P, McAuley E, Gibbons L. TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration. Acta Neuropathol. 2008;116(2):141-6.

  12. Arai T, Mackenzie IR, Hasegawa M. Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathol. 2009;117(2):125-36.

  13. Cairns NJ, Bigio EH, Mackenzie IR, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol. 2007;114(1):5-22.

  14. Miller BL, Cummings JL, Villanueva-Meyer J. Frontal lobe degeneration: clinical, neuropsychological, and SPECT characteristics. Neurology. 1991;41:1374-82.

  15. Passant U, Rosen I, Gustafson L, Englund E. The heterogeneity of frontotemporal dementia with regard to initial symptoms, qeeg and neuropathology. Int J Geriatr Psychiatry. 2005;20(10):983-8.




2020     |     www.medigraphic.com