2013, Number 1
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Arch Neurocien 2013; 18 (1)
Biochemical basis involved in sleep regulation
Díaz-Negrillo A
Language: Spanish
References: 32
Page: 42-50
PDF size: 1026.81 Kb.
ABSTRACT
Sleep medicine has received an increasing attention in research over the past years. However, the interest in
knowing the precise mechanisms that regulate the phenomena of waking and sleeping dates from ancient times.
This work intends to conduct a detailed description of the main biochemical components that regulate the sleep
process and its pathways or action mechanisms according to their excitatory, inhibitory or neuromodulatory function.
Understanding these mechanisms is crucial not only for understanding the physiological basis of sleep but also to
understand the basic principles of the treatments used in different sleep disorders.
REFERENCES
Aserinsky E, Kleitman N. Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science 1953;118:273-4.
Pappenheimer JR, Koski G, Fencl V, Karnovsky ML, Krueger JM. Extraction of sleep-promoting factor s from cerebrospinal fluid and from brains of sleep-deprived animals. J Neurophysiol 1975;38:1299-311.
Benes FM. Carlsson and the discovery of dopamine. Trends Pharmacol Scien 2001;22 (Issue 1): 46-7.
Baskys A, Remington G. Brain mechanisms and psychotropic drugs. Baskys A. Remington G. (eds.); CRC Press, New York. 1996;55-71.
Monti J, Monti D. The involvement of dopamine in the modulatión of sleep and waking. Sleep Med Rev 2007;(II):113-33.
Alcaráz Romero VM. Estructura y función del sistema nervioso. Ed. Manual Moderno. México. 2001.
Esteban Sobreviela JM, Zamorano Bayarri E, Gonçalves Estella F. Guía de buena práctica clínica en patología del sueño. Organización Médica Colegial. Madrid. 2005.
Montes Flores J, Flores Flores J, Alonso Barrón E. Histamina, receptores y antagonistas. Rev Med Hosp Gen Mex 2005; 68 (3): 164-9.
Passani MB, Giannoni P, Bucherelli C, Baldi E, Blandina P. Histamine in the brain: Beyond sleep and memory. Biochem Pharmacol 2007;73(8):1113-22.
Garrido Pertierra A, Teijón Rivera. Fundamentos de bioquímica metabólica. 2ª Ed. Tebar. Madrid. 2006.
Niswender C, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 2012; 50: 295-322
Aguirre-Navarrete RI. Bases anatómicas y fisiológicas del sueño. Rev Ecuat Neurol 2007;15:2-3.
De Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE. The hypocretins: hypothalamus-specific peptides with neuroexcitatoryactivity. Proc Natl Acad Sci USA 1998; 95: 322-7.
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM. Orexin and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998;92:573-85.
Shibata M, Mondal MS, Date Y, Nakazato M, Suzuki H. Distribution of orexinscontaining fibers and contents of orexins in the rat olfactory bulb. Neurosci Res 2008;61(1):99-105.
Zhang S, Blache D, Vercoe PE, Adam CL, Blackberry MA, Findlay PA. Expression of orexin receptors in the brain and peripheral tissues of the male sleep. Regul Pept 2005; 124(1- 3): 81-7.
Ohno K, Sakurai T. Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front Neuroendocrinol 2008;29 (1):70- 87.
Terao A, Haruyama T, Kimura K. Roles of the hypocretin/ orexins in the regulation of sleep and wakefulness. Jpn J Vet Res 2008;55(2-3):75-83.
Valencia M, Cassiani C, Cardona O, Villalobos J. El sistema orexinérgico/hipocretinérgico y su rol en los trastornos del sueño. Salud Uninorte. Barranquilla (Col) 2010;26(2):285-97.
Enna SJ, Moler H. The GABA receptors. 3rd Edition. Humana Press Inc. 2007.
Harrison NL. Mechanisms of sleep induction by GABA(A) receptor agonist. J Clin Psychiatry 2007;68 Suppl 5:6-12.
Schwierin B, Borbély AA, Tobler I. Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat. Eur J Pharmacol 1996;300:163-71.
Moriarty S, Rainnie D, McCarley R, Greene R. Desinhibition of ventrolateral preotic area sleep-active neurons by adenosine: a new mechanism for sleep promotion. Neuroscien 2004; 123:451-7.
Murillo-Rodríguez E, Blanco-Centurión C, Gerashchenko R, Salín-Pascual RJ, Shiromani PJ. The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats. Neuroscien 2004;123:361-70.
Dávila M. Neurofisiología y fisiopatología del sueño. Acta de Otorrinolaringol Cir Cab Cue 2011;39(3)Supl:37-48.
Lüllman H, Mohr K, Hein L. Farmacología. 6ª Ed. Editorial Médica Panamericana. España. 2008.
Franco Pérez J, Ballesteros Zebadúa P, Custodio V, Paz C. Principales neurotransmisores involucrados en la regulación del ciclo sueño-vigilia. Rev Inv Clín 2012; 64, 2: 182-91.
Velayos JL, Moleres A, Irujo M, Yllanes B, Paternain B. Bases anatómicas del sueño. An Sist Sanit Navar 2007; 30 (Supl.1): 7-17.
Montilla P, Túnez I. Melatonin, Present and Future. Nova Biomedical. 2007.
Paz Valiñas L. Estudio de las relaciones metabólicas y funcionales entre serotonina y melatonina en la glándula pineal de mamíferos. Aplicación de técnicas de microdiálisis in vivo. Tesis doctoral. Depto. Fisiología. Facultad de Biología. Universidad de Santiago de Compostela. 2009.
Dubocovich ML. Melatonin receptors: role on sleep and circadian regulation. Sleep Medicine 2007;8 Suppl.3:34-42.
Dominguez-Rodriguez A, Abreu Gonzalez P, Sanchez-Sanchez JJ, Kaski J, Reiter RJ. Melatonin and circadian biology in human cardiovascular disease. J Pin Res 2010;49,1:14-22.