medigraphic.com
Colegio de Medicina Interna de México.

2013, Number 6

<< Back Next >>

Med Int Mex 2013; 29 (6)

Immunosenescence and Frailty: A Current Glance

Romero-Cabrera ÁJ, Amores-Hernández L, Fernández- Casteleiro E

Language: Spanish
References: 74
Page: 605-611
PDF size: 476.06 Kb.


ABSTRACT

Immunosenescence refers to age-related changes in the immune system affecting both innate and adaptive immune response. These changes are increased in frail elderly in whom a chronic inflammatory state (inflamm-ageing) is appointed in its pathogenesis. This article reviews the nature of these changes and updates the links between inmunosenescence and frailty reflected in the current publications.


REFERENCES

  1. De la Fuente M. Role of neuroimmunomodulation in aging. Neuroinmunomod 2008;15:213-223.

  2. De la Fuente M. Role of the immune system in aging. Immunol 2008;27:176-191.

  3. Romero AJ. Fragilidad y enfermedades crónicas en los adultos mayores. Med Int Méx 2011;27:455-462.

  4. Jaafar AF, Heycock R, George J. Frailty. A clinical overview. Rev Clin Gerontol 2007;17:171-175.

  5. Karnik K, Mazzatti DJ. Review of tools and technologies to assess multi-system functional impairment and frailty. Clinical Medicine: Geriatrics 2009;3:1-8.

  6. Pawelec G. Hallmarks of human “immunosenescence”: adaptation or dysregulation? Immun Ageing 2012;9:15.

  7. Sada-Ovalle I, Gorocica P, Lascurain R, Zenteno E. Aspectos inmunológicos del envejecimiento. Rev Inst Nal Enf Resp Mex 2004;17:293-300.

  8. Gruver A, Hudson LL, Sempowski GD. Immunosenescence of ageing. J Pathol 2007;211:144-156.

  9. Aw D, Palmer DB. It’s not all equal: a multiphasic theory of thymic involution. Biogerontology 2012;13:77-81.

  10. Mitchell WA, Lang PO, Aspinall R. Tracing thymic output in older individuals. Clin Exp Immunol 2010;161:497-503.

  11. Pawelec G, McElhaney JE, Aiello AE, Derhovanessian E. The impact of CMV infection on survival in older humans. Curr Opin Immunol 2012;24:507-511.

  12. Caruso C, Buffa S, Candore G, Colonna-Romano G, et al. Mechanisms of immunosenescence. Immun Ageing 2009;6:10 doi:10.1186/1742-4933-6-10.

  13. Wills M, Akhar A, Beswick M, Bosch JA, et al. Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing 2011;8:10 doi:10.1186/1742- 4933-8-10.

  14. Derhovanessian E, Maier AB, Hachnel K, Beck R, et al. Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T cells in humans. J Gen Virol 2011;92:2746- 2756.

  15. Le Saux S, Weyand CM, Goranzy JJ. Mechanisms of immunosenescence: lessons from models of accelerated immune aging. Ann N Y Acad Sci 2012;1247:69-82.

  16. Dock JN, Effros RB. Roll of CD8 T cell replicative senescence in human aging and in HIV-mediated immunosenescence. Aging Dis 2011;2:382-397.

  17. Lindstrom TM, Robinson WH. Rheumatoid arthritis: a role for immunosenescence? J Am Geriatr Soc 2010;58:1565- 1575.

  18. Solana R, Tarazona R, Gayoso I, Lesur O, et al. Innate immunosenescence. Effect of aging on cells and receptors of the innate immune system in humans. Semin Immunol 2012;24:331-341.

  19. Wessels I, Jansen J, Rink L, Uciechowski P. Immunosenescence of polymorphonuclear neutrophils. Scientific WorldJournal 2010;10:145-160.

  20. Alonso P, de la Fuente M. Marcadores inmunológicos de envejecimiento. Rev Esp Geriatr Gerontol 2008;43:167- 179.

  21. Guayerbas N, de la Fuente M. An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice. Dev Comp Immunol 2003;24:339-350.

  22. Butcher SK. Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J Leukoc Biol 2001;70:881-886.

  23. Desai A, Grolleau-Julius A, Yung R. Leukocyte function in the aging immune system. J Leukoc Biol 2010;87:1001- 1009.

  24. Ongrádi J, Kövesdi V. Factors that may impact on immunosenescence: an appraisal. Immun Ageing 2010;7:7.

  25. Hayhoe RPG, Henson SM, Akbar AN, Palmer DB. Variation of human natural killer cell phenotypes with age: identification of a unique KLRG1 – negative subset. Hum Immunol 2010;71:678-681.

  26. Chen YJ, Liao HF. NK/NKT cells and aging. Int J Gerontol 2007;1:65-76.

  27. Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine 2000;18:1613-1620.

  28. Garroso I, Sánchez-Correa B, Campos C, Alonso C, et al. Immunosenescence of human natural killer. J Innate Immunol 2011;3:337-343.

  29. Frasca D, Díaz A, Romero M, Landin AM, Blomberg BB. Age effects on B cells and humoral immunity in humans. Ageing Res Rev 2011;10:330-335.

  30. Ongrádi J, Kapuesdi V. Numerical alterations of ageing B lymphocyte subsets. Acta Physiol Hung 2011;98:99-104.

  31. Buffa S, Bulati M, Pellicani M, Dum-Walters DK, et al. B cell immunosenescence: different features of naive and memory B cells in elderly. Biogerontology 2011;12:473-483.

  32. Bancos S, Phipps RP. Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation. Cell Immunol 2010;266:90-97.

  33. Ostan R, Bucci L, Capri M, Salvioli S, et al. Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation 2008;15:224-240.

  34. Arnold CR, Wolf J, Brunner S. Gain and loss of T cells subsets in old age-age related reshaping of the T cell repertoire. J Clin Immunol 2011;31:137-146.

  35. Larbi A, Pawelec G, Wong SC, Goldeck D, et al. Impact of age on T cell signaling: A general defect or specific alteration. Ageing Res Rev 2011;10:370-378.

  36. Henson SM, Akbar AN. Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol 2010;684:189-197.

  37. Nikolich-Zugich J, Rudd BD. Immune memory and aging: an infinite or finite resource? Curr Opin Immunol 2010;22:535-540.

  38. Lang PO, Goving S, Michel JP, Aspinall R, Mitchel WA. Immunosenescence: implications for vaccination programmes in adults. Maturitas 2011;68:322-330.

  39. McElhaney JE. Influenza vaccine responses in older adults. Ageing Res Rev 2011;10:379-388.

  40. Derhovanessian E, Solana R, Larbi A, Pawelec G. Immunity, ageing and cáncer. Immun Ageing 2008;5:11-27.

  41. Wikby A, Nilsson BO, Forsey R, Thompson J, et al. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev 2006;127:695-704.

  42. Fulop T, Larbi A, Kolb R, de Angelis F, Pawelec G. Aging, immunity and cancer. Discovery Med 2011;61:537-550.

  43. Franceschi C, Capri M, Monti D, Giunta S, et al. Inflammaging and anti-inflammaging: a systematic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007;128:92-105.

  44. Lang PO, Mitchell WA, Lapenna A, Pitts D, Aspinall R. Immunological pathogenesis of main age-related diseases and frailty: role of immunosenescence. Eur Geriatr Med 2010;1:112-121.

  45. Salvioli S, Monti D, Lanzarini C, Conte M, et al. Immune system, cell senescence, aging and longevity. Inflamaging reappraisal. Curr Pharm Des 2013;19:1675-1679.

  46. Candore G, Caruso C, Jirillo E, Magrone T, Vasto S. Low grade inflammation as a common pathogenic denominator in age-related: novel drug targets for anti-aging strategies and successful ageing achievement. Curr Pharm Des 2010;16:584-596.

  47. de la Fuente M. Role of the immune system in aging. Immunol 2008;27:176-191.

  48. Alonso-Fernández P, de la Fuente M. Role of the immune system in aging and longevity. Curr Aging Sci 2011;4:78- 100.

  49. Cannizo ES, Clement CC, Sahu R, Follo C, Santambrogio L. Oxidative stress, inflammaging and immunosenescence. J Proteomics 2011;74:2313-2323.

  50. Fried L, Tangen CM, Walston J, Newman AB, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56:146-156.

  51. Strandberg TE, Pitkäla KH, Tilvis RS. Frailty in older people. Eur Geriatr Med 2011;2:344-355.

  52. Fried LP, Xue QL, Cappola AR, Ferrucci L, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 2009;64:1049- 1057.

  53. de Vries NM, Staal JB, van Ravensberg CD, Hobbelen JSM, et al. Outcome instruments to measure frailty: a systematic review. Ageing Res Rev 2011;10:104-114.

  54. I-Chien W, Shu-Chu S, Po-Hsiu K, Xi-Zhang L. High oxidative stress is correlated with frailty in elderly Chinese. J Am Geriatr Soc 2009;57:1666-1671.

  55. Hubbard RE, O’Mahoney MS, Calver BL, Woodhouse KW. Plasma esterases and inflammation in ageing and frailty. Eur J Clin Pharmacol 2008;64:895-900.

  56. Barzilay JI, Blaum C, Moore T, Li Q, et al. Insulin resistance and inflammation as precursors of frailty. The Cardiovascular Health Study. Arch Intern Med 2007;167:635-641.

  57. Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc 2007;55:864-871.

  58. Leng S, Xue Q, Tian J. Association of neutrophil and monocyte counts with frailty in community-dwelling women. Exp Gerontol 2009;44:511-516.

  59. Li H, Manwani B, Leng S. Frailty, inflammation and immunity. Aging Dis 2011;2:466-473.

  60. Yao X, Li H, Leng SX. Inflammation and immune system alterations in frailty. Clin Geriatr Med 2001;27:79-87.

  61. Leng S, Yang H, Walston J. Decreased cell proliferation and altered cytokine production in frail older adults. Aging Clin Exp Res 2004;16:249-52.

  62. De FU, Wang GC, Fedarko NS, Walston JD, et al. Tlymphocytes expressing CC chemokine receptor-5 are increased in frail older adults. J Am Geriatr Soc 2008;56:904-908.

  63. Semba RD, Margolick JB, Leng S, Walston J, et al. T-cell subsets and mortality in older community-dwelling women. Exp Gerontol 2005;40:81-87.

  64. Gibson KL, Wu YC, Barnett Y, Duggan O, et al. B-cell diversity decreases in old age and is correlated with poor health status. Aging Cell 2009;8:18-25.

  65. Lang T, Streeper T, Cawthon P, Baldwin K, et al. Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 2010;21:543-559.

  66. Meng S, Yu L. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci 2010;11:1509-1526.

  67. Chung HY, Cesari M, Anton S, Marzetti E, et al. Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev 2009;8:18-30.

  68. Thomas DR. Sarcopenia. Clin Geriatr Med 2010;26:331- 346.

  69. Boirie Y. Physiopathological mechanism of sarcopenia. J Nutr Health Aging 2009;13:717-723.

  70. Lutz CT, Quinn LS. Sarcopenia, obesity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mechanism. Aging (Albany NY) 2012;4:535-546.

  71. Cagneta V, Patella V. The role of the immune system in the physiopathology of osteoporosis. Clin Cases Miner Bone Metab 2012;9:85-88.

  72. Zhao W, Liu Y, Cahill CM, Yang W, et al. The role of T cells in osteoporosis, an update. Int J Clin Exp Pathol 2009;2:544-552.

  73. Lambert ND, Ovsyannikova IG, Pankrats VS, Jacobson RM, Poland GA. Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach. Expert Rev Vaccines 2012;11:985-994.

  74. Hamsa SA, Mousa SM, Taha SE, Adel LA, et al. Immune response of 23-valent pneumococcal polysaccharide vaccinated elderly and its relation to frailty indices, nutritional status, and serum zinc levels. Geriatr Gerontol Int 2012;12:223-229.




2020     |     www.medigraphic.com