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ISSN 0188-9796 (Print)

2013, Number 2

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Rev Endocrinol Nutr 2013; 21 (2)

Association between polymorphism TT genotype rs1130214 of the AKT1 gene with obesity in adult population of western Mexico

Becerra-Morales E, Ramos-Márquez ME, Carrillo-Pérez MC

Language: Spanish
References: 16
Page: 69-73
PDF size: 191.79 Kb.


ABSTRACT

AKT1 protein is a serine/threonine kinase that is expressed in a wide variety of tissues including adipose tissue; it is involved in the insulin signaling pathway and in the regulation of lipolysis. Material and methods: In this study, we examined the AKT1 gene rs1130214 polymorphism in 242 unrelated persons from western Mexico, to evaluate its role in the development of obesity. The rs1130214 polymorphism was identified by PCR- RFLP. Results: Of the people studied, the 30.43% had a BMI ‹ 25, 45.22% with BMI ≥ 25 and ‹ 30, and 24.25% with BMI ≥ 30. The distribution of genotypes was in Hardy-Weinberg equilibrium. The TT genotype was more frequent in those with a BMI ≥ 30 than in those with BMI ‹ 25. For the association analysis, the statistical model applied to genetics used showed that the T allele has a recessive effect of predisposition to obesity (χ2 = 4.87, p ‹ 0.03, OR = 2.95, CI95% [1.09-7.93]). Conclusion: The results of this study show the existence of an association between the rs1130214 polymorphism and obesity in the individuals analyzed. Importantly, this finding is the first record of this polymorphism in Mexican population.


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