medigraphic.com
ISSN 1561-2996 (Electronic)
ISSN 0864-0289 (Print)

2013, Number 3

<< Back Next >>

Rev Cubana Hematol Inmunol Hemoter 2013; 29 (3)

Absolute lymphocyte count as a predictor in hematopoietic transplantation

Romero GA, Jaime FJC, Pinedo GL, Quintero SY, Gil AM, Mustelier CGL

Language: Spanish
References: 50
Page:
PDF size: 64.42 Kb.


ABSTRACT

Early recovery of lymphocytes is a prognostic factor that is related to a higher eventfree survival and overall survival after haematopoietic stem cell transplantation. A literature review was conducted in order to determine the prognostic value of absolute lymphocyte count in patients with hematological malignancies after transplantation. Autologous transplant patients reach an absolute lymphocyte count on day + 15 (RAL15) e» 500 x mm3, earlier than allogeneic. The RAL15 when peripheral blood is used is greater than when using the bone marrow. Prognostic factors associated with worse overall survival were sepsis, RAL 15 ‹500x mm3 and relapse. Several studies show a better overall survival and event-free survival at five years in patients with e» 500 x RAL15 mm3. The RAL15 e» 500 x mm3 is a simple and useful tool to predict a better outcome in patients undergoing hematopoietic transplantation.


REFERENCES

  1. Jaime JC, Dorticós E, Pavón V, Cortina Rosales L. Trasplante de células progenitoras hematopoyéticas: tipos, fuentes e indicaciones. Rev Cub Hematol Inmunol Hemoter. 2004 Ago [citado 2009 Feb 11] ; 20(2):Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 02892004000200002&lng=es

  2. Deeg H, DiPersio J, Young J, Maziarz R, Perreault C, Margolis D, et al. ASBMT policy statement 2009 research priorities. Biol Blood Marrow Transplant. 2009 Feb;13(2):148991.

  3. Santos GW. History of bone marrow transplantation. Clin Haematol. 1983 Oct;12(3):611-39.

  4. Remberger M, Mattsson J, Hentschke P, Aschan J, Barkholt L, Svennilson J et al. The graft-versus-leukemia effect in haematopoietic stem cell transplantation using unrelated donors. Bone Marrow Transplant.2002 Dec 30(11):761-8.

  5. Block MS, Markovic SN. The tumor/immune interface: clinical evidence of cancer immunosurveillance, immunoediting and immunosubversion, Am J of Immunol. 2009 Sep 5:13(1):2949.

  6. Storek J. Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood.2001 Jun 1;97(11):3380-9.

  7. Nguyen VH, Shashidhar S, Chang DS. The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation. Blood. 2008 Jan 15; 111(2):945-53.

  8. Comoli P, Basso S, Zecca M. Preemptive therapy of EBV-related lymphoproliferative disease after pediatric haploidentical stem cell transplantation. Am J Transplant. 2007 Jun; 7(6):1648-55.

  9. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62.

  10. Kim DH, Kim JG, Sohn SK. Clinical impact of early absolute lymphocyte count after allogeneic stem cell transplantation. Br J Haematol. 2009 Jan; 9(1):57-62.

  11. Guillermo AD, Carrie Y, Shana LP, Peter MA. Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies. Cancer. 2008 Jan 15;112(2):407-15.

  12. Boulassel MR, Herr AL, deB Edwardes MD, Galal A, Lachance S, Laneuville P, et al. Early lymphocyte recovery following autologous peripheral stem cell transplantation is associated with better survival in younger patients with lymphoproliferative disorders. Hematology. 2006 Jun;11(3):165-70.

  13. Porrata LF, Markovic SN. Timely reconstitution of immune competence affects clinical outcome following autologous stem cell transplantation, Clinical and Experimental Medicine. Clin Exp Med. 2004 Oct; 4(2):78-85.

  14. Takasaki H, Numata A, Tachibana T, Tanaka M, Maruta A, Ishigatsubo Y, et al. Relationship between early lymphocyte recovery and prognosis after allogeneic hematopoietic stem cell transplantation for acute leukemia in remission. Rinsho Ketsueki. 2011 Jan; 52(1):1-7.

  15. Porrata F, Gertz A, Litzow R. Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation for patients with primary systemic amyloidosis. Clin Can Res. 2005 Feb 1; 11(3):1210-8.

  16. Joao C, Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, et al. Early lymphocyte recovery after autologous stem cell transplantation predicts superior survival in mantle-cell lymphoma. Bone Marrow Transplant. 2006 May; 37(9):865-71.

  17. Kim H, Sohn HJ, Kim SE, Kang HJ, Parks S, Kim S et al. Lymphocyte recovery as a positive predictor of prolonged survival after autologous peripheral blood stem cell transplantation in T-cell non-Hodgkin's lymphoma. Bone Marrow Transplant. 2004 Jul; 34(1):43-9.

  18. Porrata LF, Gertz MA, Inwards DJ, Litzow MR, Lacy MQ, Tefferi A, et al. Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma. Blood. 2001 Aug 1; 98(3):579-85.

  19. Porrata LF, Litzow MR, Tefferi A, Letendre L, Kumar S, Geyer SM, et al. Early lymphocyte recovery is a predictive factor for prolonged survival after autologous hematopoietic stem cell transplantation for acute myelogenous leukemia. Leukemia. 2002 Jul; 16(7):1311-8.

  20. Pasquini MC, Wang Z. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides.2010 [citado 2 de febrero 2011] Disponible en: http://www.cibmtr.org

  21. Behl D, Porrata LF, Markovic SN, Letendre L, Pruthi RK, Hook CC, et al. Absolute lymphocyte count recovery after induction chemotherapy predicts superior survival in acute myelogenous leukaemia. Leukemia. 2006 Jan;20(1):29-34.

  22. Bühlmann L, Buser AS, Cantoni N, Gerull S, Tichelli A, Gratwohl A, et al. Lymphocyte subset recovery and outcome after T-cell replete allogeneic hematopoietic SCT. Bone Marrow Transplant. 2011 Oct;46(10):1357-62. doi: 10.1038/bmt.2010.306.

  23. Palmer S, Hanson CA, Cent CS, Porrata LF, Laplant B, Geyer SM. Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic limphocytic leukaemia. Br J Haematol. 2008 May;141(5):607-14.

  24. Matthews K, Lim Z, Pearce L, Pagliuca A, Madrigal JA, Mufti GJ. Rapid recovery of lymphocyte subsets is not associated with protection from relapse of myelodysplastic syndromes and acute myeloid leukaemia after haematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Br J Haematol. 2010 Jun;149(6):879-89.

  25. Jacobs N. L, Holtan S. G, Porrata L. F, Markovic S. N, Tefferi A, Steensma D. P. Low absolute lymphocyte count (ALC) at diagnosis is an IPSS-independent predictor of poorer survival in myelodysplastic syndrome (MDS).Blood, 2008 ;112, abs 3633.

  26. Porrata LF, Ingle JN, Litzow MR, Geyer S, Markovic SN. Prolonged survival associated early limphocyte recovery after autologous hematopoietic stem cell transplantation for patients with metastatic breast cancer. Bone Marrow Transplant. 2001 Nov; 28(9):865-71.

  27. Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C. Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome. Pancreas. 2006 Jan;32(1):22-8.

  28. Moore C, Eslin D, Levy A, Roberson J, Giusti V, Sutphin R. Prognostic significance of early lymphocyte recovery in pediatric osteosarcoma. Pediatr Blood Cancer. 2010 Dec 1; 55(6):1096-102.

  29. De Angulo G, Hernandez M, Morales-Arias J, Herzog CE, Anderson P, Wolff J. Early lymphocyte recovery as a prognostic indicator for high-risk Ewing sarcoma. J Pediatr Hematol Oncol. 2007 Jan;29(1):48-52.

  30. DuBois SG, Elterman K, Grier HE. Early lymphocyte recovery in Ewing sarcoma. J Pediatr Hematol Oncol. 2007 May;29(5):351-2.

  31. De Angulo G, Yuen C, Palla SL, Anderson PM, Zweidler-McKay PA. Absolute lymphocyte count is a novel prognostic indicator in ALL and AML: implications for risk stratification and future studies. Cancer. 2008 Jan 15;112(2):407-15.

  32. Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia: A review. Environ Health Perspect. 2007 Jan;115(1):138-45.

  33. Venepalli N, Rezvani K, Mielke S, Savani BN. Role of allo-SCT for CML in 2010. Bone Marrow Transplant. 2010 Nov; 45(11):1579-86.

  34. Mustjoki S, Lundán T, Knuutila S, Porkka K. Appearance of bone marrow lymphocytosis predicts an optimal response to imatinib therapy in patients with chronic myeloid leukemia. Leukemia. 2007 Nov; 21(11):2363-8.

  35. Porrata LF, Markovic SN. Is absolute lymphocyte count just another prognostic factor in cancer? SRX Medicine. 2010; (2010), Article ID 812304, 8 pages. doi:10.3814/2010/812304

  36. Pidala J, Anasetti C, Kharfan-Dabaja MA, Cutler C, Sheldon A, Djulbegovic B. Decision analysis of peripheral blood versus bone marrow hematopoietic stem cells for allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2009 Nov; 15(11):1415-21.

  37. Stem Cell Trialists' Collaborative Group. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials.J Clin Oncol. 2005 Aug 1; 23(22):5074-87.

  38. Porrata LF. Clinical evidence of autologous graft-versus-tumor effect. Am J Immunol. 2009; 5:1-7.

  39. Kim H, Sohn HJ, Kim S, Lee JS, Kim WK, Suh C. Early lymphocyte recovery predicts longer survival after autologous peripheral blood stem cell transplantation in multiple mieloma. Bone Marrow Transplant. 2006; 37:1037-42.

  40. Siddiqui M, Ristow K, Markovic SN, Witzig TE, Habermann TM, Colgan JP, et al. Absolute lymphocyte count predicts overall survival in follicular lymphomas. Br J Haematol. 2006 Sep; 134(6):596-601.

  41. Ege H, Gertz MA, Markovic SN, Lacy MQ, Dispenzieri A, Hayman SR, et al. Prediction of survival using absolute lymphocyte count for newly diagnosed patients with multiple myeloma: a retrospective study. Haematol. 2008 Jun; 141(6):792-8.

  42. Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, Gastineau DA, et al. Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective study. Biol Blood Marrow Transplant. 2008 Jul; 14(7):807-16.

  43. Chen J, Wang JM, Zhang WP, Song XM, Qiu HY, Xu XQ, et al. Relationship between the absolute lymphocyte count before or after autologous hematopoietic stem cell ransplantation and the prognosis in patients with non-Hodgkin's lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2010 Aug; 31(8):510-514.

  44. Barrett AJ, Savani BN, «Does chemotherapy modify the immune surveillance of hematological malignancies?» Leukemia. 2009 Jan; 23(1):53-8.

  45. Oki Y, Yamamoto K, Kato H, Kuwatsuka Y, Taji H, Kagami et al. Low absolute lymphocyte count is a poor prognostic marker in patients with diffuse large B-cell lymphoma and suggests patients' survival benefit from rituximab. Eur J Haematol. 2008 Dec;81(6):448-53.

  46. Cox MC, Nofroni I, Ruco L, Amodeo R, Ferrari A, La Verde G, et al. Low absolute lymphocyte count is a poor prognostic factor in diffuse-large- B-cell-lymphoma. Leuk Lymph. 2008 Sep;49(9):1745-51.

  47. Cox MC, Nofroni I, Ruco L, Amodeo R, Ferrari A, La Verde G, et al., Absolute lymphocyte count is a prognostic factor in diffuse large B-cell lymphoma. Brit J Haematol.2008 Sep;141(2):265-8.

  48. I Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Le Cesne A, Judson I, et al. Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res. 2009 Jul 1;69(13):5383-91.

  49. Ege H, Gertz MA, Markovic SN, Lacy MQ, Dispenzieri A, Hayman SR, et al. Prediction of survival using absolute lymphocyte count for newly diagnosed patients with multiple myeloma: a retrospective study. Br J Haematol. 2008 Jun;141(6):792-8.

  50. Chang YJ, Zhao XY, Huo MR, Xu LP, Liu DH, Liu KY, et al.Clinical impact of absolute lymphocyte count on day 30 after unmanipulated haploidentical blood and marrow transplantation for pediatric patients with hematological malignancies.Am J Hematol. 2011 Feb; 86(2):227-30.




2020     |     www.medigraphic.com