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2013, Number 2

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Revista Cubana de Angiología y Cirugía Vascular 2013; 14 (2)

Uric acid and its capability to be a risk factor for vascular disease or not

Álvarez PM, Triana MME

Language: Spanish
References: 67
Page:
PDF size: 125.85 Kb.


ABSTRACT

Introduction: the biological function and the role of uric acid in some diseases that can cause the death in the world are known, but its role as risk factor to vascular diseases is under debate.
Objective: to deepen into the role of uric acid in peripheral vascular diseases.
Data source: literature review of the last ten years was performed. MedLine, Cochrane and PubMed electronic databases were consulted as well as Academic GOOGLE and other web sites. The following key words were used: uric acid, oxidative stress, risk factors, diabetes mellitus, atherosclerosis, cardiovascular diseases, peripheral arterial disease and venous ulcers. An exhaustive analysis was made to determine the participation of uric acid in the physiopathology of vascular diseases.
Results: information that links uric acid with vascular diseases was found, but its participation in the etiopathogenia of these diseases is not clear yet. The results of some studies point out that there could be both a beneficial effect and a prejudicial one in the physiopathology in these diseases and also, a new function could be added: its participation in ulcers cicatrisation in lower limbs.
Conclusions: it has not been possible to reach a consensus on the fact that uric acid is a risk factor or not to vascular disease or if it increases the effects of the factors already present from what, in the future, it is necessary to fill in the space information existing and define the role of this compound in the prevention and control of these diseases.


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