Ochoa-Guzmán A, Chiquete E, Cantú-Brito C, Arauz A, Murillo-Bonilla L, Villarreal-Careaga J, Ruiz-Sandoval JL

Language: Spanish
References: 18
Page: 463-469
PDF size: 155.95 Kb.

ABSTRACT

Introduction: Little is known about the frequency and clinical outcome of cases with lupus-associated acute cerebrovascular disease in Mexico. Objective: To describe the prevalence and short-term outcome of lupus erythematosus in patients with the major forms of acute cerebrovascular disease in the Mexican multicenter registry RENAMEVASC. Methods: A total of 2000 patients were studied in the RENAMEVASC registry in 25 hospitals from 14 states of Mexico: 100 (5%) with transient ischemic attack (TIA), 992 (49.6%) with acute cerebral infarction (ACI), 580 (29%) with intracerebral hemorrhage (ICH), 269 (13.5%) with subarachnoid hemorrhage (SAH), and 59 (3%) with cerebral venous thrombosis (CVT). Results: In all, the prevalence of lupus erythematosus was 1.3% (95% confidence interval: 0.8-1.9%), significantly higher among cases with CVT (3.4%), than in SAH patients (0.4%, p = 0.03), but not higher than ICH (0.9%, p = 0.07), ICT (2%, p = 0.59) or ACI (1.6%, p = 0.31) cases. Compared with patients without lupus, those with this condition were significantly younger, with a high proportion of the female gender and antiphospholipid syndrome (in all, p ‹ 0.05). Shortterm outcome of lupus patients was, in general, favorable, with an acute mortality not significantly different from patients without lupus (7.6 vs. 20.7%, respectively; p = 0.10), but with a lower proportion of cases with a modified Rankin score › 3 at dischrage (modified Rankin scale › 3, 11.5% vs. 49.4%, respectively; p ‹ 0.001) and at 30-day follow-up (11.5 vs. 43%, respectively; p = 0.001). Conclusion: In Mexico, the frequency of lupus erythematosus in patients with acute cerebrovascular disease is ‹ 2% and with shortterm mortality ‹ 10%.

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