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2013, Number 2

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AbanicoVet 2013; 3 (2)

The young pig as biomarker of low concentrations of genotoxic using micronuclei erythrocytes

Cedano DA, Martínez-González S, Torres-Bugarín O, Trujillo-Hernández B, Zúñiga-González G, Peña-Parra B

Language: Spanish
References: 32
Page: 39-47
PDF size: 406.01 Kb.


ABSTRACT

The aim of this was to determine the response of the young pig erythrocyte micronuclei (10-13 weeks / age) exposed to cyclophosphamide (0.5, 1.0, 2.0 and 4.0 mg / kg), for use as a biomarker of low concentrations of genotoxic. Thus, in pigs induced with cyclophosphamide found significant increases in the number of micronucleated cells in the treatments of 0.5, 1.0 and 4 mg / kg of cyclophosphamide. So we conclude that young pigs (10-13 weeks / age) show micronucleated erythrocyte response to cyclophosphamide, even at lower doses than recommended for rodent evidence of chromosomal damage. Therefore, the pig can be considered as a reliable test to detect genotoxic agents micronucleated.


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