medigraphic.com
Academia Mexicana de Neurología, A.C.

2010, Number 1

<< Back Next >>

Rev Mex Neuroci 2010; 11 (1)

Melanin-concentrating hormone (MCH): hypothalamic neuropeptide that facilitates the generation of sleep

Torterolo P, Castro S, Falconi V, Lagos P

Language: Spanish
References: 40
Page: 46-51
PDF size: 155.13 Kb.


ABSTRACT

The MCHergic system consists of hypothalamic neurons that utilize the neuropeptide melanin-concentrating hormone (MCH) as neuromodulador. The MCHergic neurons project towards diverse regions of the central nervous system, such as the areas involved in the control of sleep and wakefulness. Numerous studies have involved the MCHergic system with the control of the energy homeostasis. Nevertheless, recent studies have begun to show a role of this system in the regulation of sleep and wakefulness, especially in the control of REM sleep.
In this work we briefly reviewed the physiology of the MCHergic system, focusing in the relationship of this system with the control of sleep.


REFERENCES

  1. Saito Y and Nagasaki H. The melanin-concentrating hormone system and its physiological functions. Results Probl Cell Differ 2008; 46: 159-79.

  2. Nahon J L. The melanocortins and melanin-concentrating hormone in the central regulation of feeding behavior and energy homeostasis. C R Biol 2006; 329: 623-38; discussion 653-5.

  3. Kawauchi H, Kawazoe I, Tsubokawa M, Kishida M and Baker B I. Characterization of melanin-concentrating hormone in chum salmon pituitaries. Nature 1983; 305: 321-23.

  4. Bittencourt J C, Presse F, Arias C, Peto C, Vaughan J, Nahon J L, et al. The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992; 319: 218-45.

  5. Torterolo P, Sampogna S, Morales F R and Chase M H. MCHcontaining neurons in the hypothalamus of the cat: Searching for a role in the control of sleep and wakefulness. Brain Res 2006; 1119: 101-14.

  6. Mouri T, Takahashi K, Kawauchi H, Sone M, Totsune K, Murakami O, et al. Melanin-concentrating hormone in the human brain. Peptides 1993; 14: 643-6.

  7. Bernardis L L and Bellinger L L. The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 1996; 20: 189-287.

  8. Shi Y. Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions. Peptides 2004; 25: 1605-11.

  9. Forray C. The MCH receptor familiy: feeding brain disorders? Curr Opin Pharmacol 2003; 3: 85-9.

  10. Bittencourt J and Celis M E. Anatomy, function and regulation of neuropeptide EI (NEI). Peptides 2008; 29: 1441-50.

  11. Tan C P, Sano H, Iwaasa H, Pan J, Sailer A W, Hreniuk D L, et al. Melanin-concentrating hormone receptor subtypes 1 and 2: speciesspecific gene expression. Genomics 2002; 79: 785-92.

  12. Gao X B and van den Pol A N. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol 2001; 533: 237-52.

  13. Gao X B and van den Pol A N. Melanin-concentrating hormone depresses L-, N-, and P/Q-type voltage-dependent calcium channels in rat lateral hypothalamic neurons. J Physiol 2002; 542: 273-86.

  14. Rao Y, Lu M, Ge F, Marsh D J, Qian S, Wang A H, et al. Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. J Neurosci 2008; 28: 9101-10.

  15. Torterolo P, Sampogna S and Chase M H. MCHergic projections to the nucleus pontis oralis participate in the control of active (REM) sleep. Brain Res 2009; 1268: 76-87.

  16. McGregor R, Damian A, Fabbiani G, Torterolo P, Pose I, Chase M, et al. Direct hypothalamic innervation of the trigeminal motor nucleus: a retrograde tracer study. Neuroscience 2005; 136: 1073-81.

  17. Torterolo P, Lagos P, Sampogna S and Chase M H. Melaninconcentrating hormone (MCH) immunoreactivity in non-neuronal cells within the raphe nuclei and subventricular region of the brainstem of the cat. Brain Res 2008; 1210: 163-178.

  18. Borowsky B, Durkin M M, Ogozalek K, Marzabadi M R, DeLeon J, Heurich R, et al. Antidepressant, anxiolytic and anorectic effects of a melanin- concentrating hormone-1 receptor antagonist. Nat Med 2002; 8: 825-30.

  19. Torterolo P, Scorza C, Lagos P, Urbanavicius J, Miraballes R, Jantos H, et al. Melanin-concentrating hormone (MCH) in the dorsal raphe nucleus: role in REM sleep and depression. Sleep Medicine 2009; 10: S61.

  20. Lagos P, Urbanavicius J, Scorza C, Miraballes R and Torterolo P. Depression-like profile produced by Melanin Concentrating Hormone (MCH) microinjections into the dorsal raphe nucleus. Effects of Fluoxetine. Submitted 2009;

  21. Cirelli C. Cellular consequences of sleep deprivation in the brain. Sleep Med Rev 2006; 10: 307-21.

  22. Jones B. Basic mechanisms of sleep-wake states. In: Kryger MH, Roth T, Dement WC (eds.). Principles and practices of sleep medicine. Philadelphia: Elsevier-Saunders; 2005,pp. 136-53.

  23. Torterolo P, Rojas M, Sampogna S, Morales FR, Chase M H. MCHcontaining neurons and the control of sleep and wakefulness. Sleep 2003; 26: A20.

  24. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Leger L, et al. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 2003; 4: 19.

  25. Modirrousta M, Mainville L, Jones BE. Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci 2005; 21: 2807-16.

  26. Ahnaou A, Drinkenburg WH, Bouwknecht JA, Alcazar J, Steckler T, Dautzenberg FM. Blocking melanin-concentrating hormone MCH(1) receptor affects rat sleep-wake architecture. Eur J Pharmacol 2008; 579: 177-88.

  27. Lagos P, Torterolo P, Jantos H, Chase MH, Monti JM. Effects on sleep of melanin-concentrating hormone microinjections into the dorsal raphe nucleus. Brain Res 2009; 1265: 103-10.

  28. Adamantidis A, Salvert D, Goutagny R, Lakaye B, Gervasoni D, Grisar T, et al. Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice. Eur J Neurosci 2008; 27: 1793- 800.

  29. Willie J T, Sinton C M, Maratos-Flier E, Yanagisawa M. Abnormal response of melanin-concentrating hormone deficient mice to fasting: Hyperactivity and rapid eye movement sleep suppression. Neuroscience 2008; 156: 819-29.

  30. Hassani O K, Lee MG, Jones BE. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A 2009; 106: 2418-22.

  31. Benington J H and Heller H C. Restoration of brain energy metabolism as the function of sleep. Prog Neurobiol 1995; 45: 347-60.

  32. Torterolo P, Vanini G. Rol del sistema hipocretinérgico en la fisiología y patología del sueño. Avances de la medicina del sueño en latinoamérica 2007; 2: 5-12.

  33. Torterolo P, Yamuy J, Sampogna S, Morales FR, Chase M H. Hypocretinergic neurons are primarily involved in activation of the somatomotor system. Sleep 2003; 1: 25-28.

  34. Torterolo P, Yamuy J, Sampogna S, Morales F R and Chase M H. Hypothalamic neurons that contain hypocretin (orexin) express cfos during active wakefulness and carbachol-induced active sleep. Sleep Res Online 2001; 4: 25-32. http://www.sro.org/2001/Torterolo/25.

  35. van den Pol A N, Acuna-Goycolea C, Clark K R and Ghosh P K. Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron 2004; 42: 635-52.

  36. Peyron C, Tighe D K, van den Pol A N, de Lecea L, Heller H C, Sutcliffe J G, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18: 9996-10015.

  37. Rivera G, Bocanegra-Garcia V, Galiano S, Cirauqui N, Ceras J, Perez S, et al. Melanin-concentrating hormone receptor 1 antagonists: a new perspective for the pharmacologic treatment of obesity. Curr Med Chem 2008; 15: 1025-43.

  38. Adrien J. Neurobiological bases for the relation between sleep and depression. Sleep Med Rev 2002; 6: 341-51.

  39. Aziz A, Fronczek R, Maat-Schieman M, Unmehopa U, Roelandse F, Overeem S, et al. Hypocretin and melanin-concentrating hormone in patients with Huntington disease. Brain Pathol 2008; 18: 474-83.

  40. Thannickal T C, Lai Y Y and Siegel J M. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain 2007; 130: 1586-95.




2020     |     www.medigraphic.com