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2013, Number 3

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Gac Med Mex 2013; 149 (3)

Positive surgical margins decrease cancer-specific survival of patients with prostate cancer treated with radical prostatectomy

Arceo-Olaiz R, de Anda-González J, Urbina-Ramírez S, Sotomayor ZM, Castillejos-Molina R, Gabilondo-Navarro F, Feria-Bernal G, Rodríguez-Covarrubias F

Language: Spanish
References: 28
Page: 286-291
PDF size: 87.08 Kb.


ABSTRACT

Objective: To assess the impact of positive surgical margins (PSM) on cancer-specific survival (CSS) of patients with clinically localized prostate cancer (PCa) treated with radical prostatectomy. Methods: We retrospectively analyzed our PCa database. Patients were classified in Group 1 (negative surgical margins) and Group 2 (PSM). An expert pathologist reevaluated all slides. The main outcome was CSS. We used Kaplan-Meier method and Mantel-Cox test for survival analysis as well as Cox proportional hazards test to determine risk factors of mortality. Results: 311 patients with PCa undergoing surgery from 1988 to 2011 were assessed. Follow-up time was 52.9 ± 43.2 months. Group 1 consisted of 214 and Group 2 of 97 individuals (PSM in 31%). The later had higher prostate-specific antigen and Gleason score, as well as more advanced pathological stage. The 10-year CSS was 94 and 76% for Groups 1 and 2, respectively (p = 0.004). On multivariate analysis, PSM and pathological stage predicted PCa related mortality. Conclusion: Surgical margin invasion and advanced pathological stage on prostatectomy specimen decrease CSS of patients with PCa.


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