Beltrán RO, Rivas MMI, Bruno CG, Villa TS

Language: Spanish
References: 21
Page: 219-224
PDF size: 178.44 Kb.

ABSTRACT

Introduction. Caffeic acid phenethyl ester (CAPE), a propolis component, has shown anticarcinogenic properties in the modified resistant hepatocyte model, when is administered before initiation. However, is unknown if has the same protector effect on promotion stage. In this work was characterized its effect when is administered during promotion stage, measuring preneoplastic lesions originated by the carcinogenic treatment. Hypothesis. CAPE reduce the preneoplastic lesions when is administered during promotion stage of the hepatocarnogenesis process. Material and methods. Male Fischer-344 rats were treated like in the modified resistant hepatocyte model as control group. As problem group, were administered several doses by gavage of CAPE (20 mg/kg). The animals were sacrificed on day 25th, the liver was extracted for GGT histochemical analysis. Statistical analysis was done using one way ANOVA and a p value < 0.05. Results. CAPE diminished the preneplastic lesions, 75% in foci number per cm2 and 62.3% in GGT positive area. Conclusions. CAPE reduced the induction of preneoplastic lesions when is administered in the middle of hepatocarcinogenesis, demonstrating been a potential chemoprotector that could be used on humans in future.

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