medigraphic.com

2012, Number 3

<< Back Next >>

Med Sur 2012; 19 (3)

Correlación entre funciones ejecutivas y volúmenes cerebrales de pacientes adultos mayores con y sin déficit cognitivo

Tovar-Rivera E, López-Martínez C, Becerra-Laparra IK, Gómez-Sandoval C, Roldán-Valadez EA

Language: Spanish
References: 50
Page: 149-155
PDF size: 86.85 Kb.


ABSTRACT

Introduction. The prefrontal cortex (PFC) is the area that presents the greatest loss in volume as you age. The decrease of the executive functions of the elderly themselves have been linked to this atrophy without associated neurological disease. Objective. To analyze the association between tests performance that assess executive functions and prefrontal cortex volume in elderly patients without cognitive impairment and Alzheimer’s disease patients. Material and methods. We included 20 patients aged 65 years or older, 10 previously diagnosed with Alzheimer’s disease and 10 without cognitive impairment. Underwent an assessment of executive functions and skull MRI volumetry and post processing sequence diffusion tensor. Results. Patients without cognitive impairment: mean age 71 years, 7 women and 3 men, average volume of PFC: 69.38 cm3, mean score on the frontal assessment battery: 15.4 points. Patients with Alzheimer’s disease: mean age 76.8 years, 8 women and 2 men, average volume of the PFC: 55.77cm3, mean score on the Frontal Assessment Battery: 10.1 points. Conclusions. In patients without cognitive impairment correlation between the volume of the PFC and frontal assessment battery was negative correlations; with semantic fluency and digit span were positive. In AD patients was positive correlation between the volume of the PFC and executive function tests. Brain volumes were lower in patients with AD. The frontal assessment battery performance and semantic fluency was significantly higher in patients without cognitive impairment.


REFERENCES

  1. Dekaban AS. Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol 1978; 4: 345-56.

  2. Svennerholm L, Boström K, Jungbjer B. Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol 1997; 94: 345-52.

  3. Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC. A longitudinal study of brain volume changes in normal ageing using serial registered magnetic resonance imaging. Arch Neurol 2003; 60: 989-94.

  4. DeCarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R, Beiser A. Measures of brain morphology and infarction in the Framingham Heart Study: establishing what is normal. Neurobiol Aging 2005; 26: 491-510.

  5. Pakkenberg B, Gundersen HJG. Neocortical neuron number in human: Effect of sex and age. J Comparative Neurology 1997; 384: 312-20.

  6. Bartzokis G, Cummings JL, Sultzer D, Henderson VW, Nuechterlein KH, Mintz J. White matter structural integrity in healthy aging adults and patients with Alzheimer disease. Arch Neurol 2003; 60: 393-8.

  7. Cabeza R. Cognitive Neuroscience of Aging. Linking cognitive and cerebral aging. Oxford University Press 2004; 300-57.

  8. Raz N. The ageing brain: structural changes and their implications for cognitive ageing. New frontiers in cognitive ageing. Oxford University Press 2004; 115-34.

  9. Diamond A. Normal development of prefrontal cortex from birth to young adulthood: cognitive function, anatomy, and biochemistry. Principles of frontal lobe function. Oxford University Press 2002; 466-503.

  10. Sasson E, Doniger GM, Pasternak O, Tarrasch R, Assaf Y. Structural correlates of cognitive domains in normal aging with diffusion tensor imaging. Brain Struct Funct 2012; 217: 503-15.

  11. Tirapu-Ustárroz J, Muñoz-Céspedes JM, Pelegrín-Valero C. Funciones ejecutivas: necesidad de una integración conceptual. Rev Neurol 2002; 34: 673-85.

  12. Fernandez-Duque D, Baird JA, Posner M. Executive attention and metacognitive regulation. Consciousness and Cognition 2000; 9: 288-307.

  13. Spar JE, La Rue A. Clinical manual of geriatric psychiatry. 1st Ed. American Psychiatric Publishing, Inc.; 2006.

  14. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of theNINCDS ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984; 34(7): 939-44.

  15. Rosow B. A guttman scale for the aged. J Gerontology 1966; 21: 556-9.

  16. Nagi SZ. An epidemiology of disability among adults in the United States. Health and Society 1976; 54: 439-67.

  17. Katz S, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the age: The index of ADL: a standardized measure of biological and psychosocial function. JAMA 1963; 185: 914-9.

  18. Mahoney FI. Functional evaluation: the Barthel Index. Md Med J 1965; 14: 61-5.

  19. Lawton MP. Assessment of older people: selfmaintaining and instrumental activities of daily living. Gerontologist 1969; 9: 179-86.

  20. Vellas B, Garry P. Mini nutritional assessment: A practical assessment tool for grading the nutritional state of elderly patients. Facts Res Gerontol 1994; 12: 15-55.

  21. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1982; 17(1): 37-49.

  22. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12(3): 189-98.

  23. Agrell B. The clock-drawing test. Age and Ageing 1998; 27: 399-403.

  24. Dubois B, et al. The FAB: a Frontal Assessment Battery at bedside. Neurology 2000; 55(11): 1621-6.

  25. Weschler, Wechsler Adult Intelligence Scale–Revised. New York: The Psychological Corporation 1981.

  26. Ostrosky-Solis F, Ardila A, Rosselli M, NEUROPSI: a brief neuropsychological test battery in Spanish with norms by age and educational level. J Int Neuropsychol Soc 1999; 5(5): 413-33.

  27. Alemán-Gómez Y, Melie-García L, Valdés-Hernández P. IBASPM: toolbox for authomatic parcellation of brain structures. in 12th Annual Meeting of the Organization for Human Brain Mapping 2006

  28. Bammer R, Acar B, Moseley ME. In vivo MR tractography using diffusion imaging. Eur J Radiol 2003; 45(3): 223-34.

  29. Ciccarelli O, Toosy AT, Parker GJ, Wheeler-Kingshott CA, Barker GJ, Miller DH, Thompson AJ. Diffusion tractography based group mapping of major white-matter pathways in the human brain. Neuroimage 2003; 19(4): 1545-55.

  30. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 1995; 8(7-8): 333-44.

  31. Di Paola M, Spalletta G, Caltagirone C. In vivo structural neuroanatomy of corpus callosum in Alzheimer’s disease and mild cognitive impairment using different MRI techniques: a review. J Alzheimers Dis 2010; 20(1): 67-95.

  32. Chan YH. Biostatistics 104: correlational analysis. Singapore Med J 2003; 614-9.

  33. Esiri MM, Hyman BT, Beyreuther K, Masters CL. Ageing and dementia. In: Graham DI, Lantos PL, eds. Greenfield’s neuropathology. 6th ed. London: Arnold; 1997, p. 153-234.

  34. Drachman DA. Aging of the brain, entropy, and Alzheimer disease. Neurology 2006; 24; 67: 1340-52.

  35. Pearson RCA, Esiri MM, Hiorns RW, Wilcock GK, Powell TPS. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer’s disease. Proc Natl Acad Sci 1985; 82: 4531-4.

  36. Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Arch Neurol 2001; 58: 1403-8.

  37. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14: 21-36.

  38. Karas GB, Burton EJ, Rombouts SA, van Schijndel RA, O’Brien JT, Scheltens P, McKeith IG, et al. A comprehensive study of gray matter loss in patients with Alzheimer’s disease using optimized voxel-based morphometry. Neuroimage 2003; 18: 895-907.

  39. Lee BC, Mintun M, Buckner RL, Morris JC. Imaging of Alzheimer’s disease. J Neuroimaging 2003; 13: 199-214.

  40. Jack CR Jr, Petersen RC, Xu Y, O’Brien PC, Smith GE, Ivnik RJ, Boeve BF, et al. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology 2000; 55: 484-9.

  41. Neil J, Miller J, Mukherjee P, Hüppi PS. Diffusion tensor imaging of normal and injured developing human brain - a technical review. NMR Biomed 2002; 15(7-8): 543-52.

  42. Duarte A, Hayasaka S, Du A, Schuff N, Jahng GH, Kramer J, Miller B, et al. Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer’s disease. Neurosci Lett 2006; 406: 60-5.

  43. Sowell ER, Delis D, Stiles J, Jernigan TL. Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc 2001; 7: 312-22. 44. Foster JK, Meikle A, Goodson G, Mayes AR, Howard M, Sunram SI, Cezayirli E, et al. The hippocampus and delayed recall: bigger is not necessarily better? Memory 1999; 7: 715-32.

  44. Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, et al. Hippocampal volume and retention in Alzheimer’s disease. J Int Neuropsychol Soc 2004; 10: 639-43.

  45. Deweer B, Lehericy S, Pillon B, Baulac M, Chiras J, Marsault C, Agid Y, et al. Memory disorders in probable Alzheimer’s disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry 1995; 58: 590-7.

  46. Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, van Belle G, et al. Dementia and Alzheimer disease incidence:a prospective cohort study. Arch Neurol 2002; 59: 1737-46.

  47. Rodriguez del Alamo A, Catalan Alonso MJ, Carrasco Marin L. FAB: a preliminar Spanish application of the frontal assessment battery to 11 groups of patients. Rev Neurol 2003; 36(7): 605-8.

  48. Pardo JV, Lee JT, Sheikh SA, Surerus-Johnson C, Shah H, Munch KR, Carlis JV, et al. Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging. Neuroimage 2007; 35(3): 1231-7.

  49. Martin A, Wiggs CL, Lalonde F, Mack C. Word retrieval to letter and semantic cues: A double dissociation in normal subjects using interference tasks. Neuropsychologia 1994; 28: 823-9.

  50. D’Esposito M. The dependence of span and delayed-responseperformance on prefrontal cortex. Neuropsychologia 1999; 37: 1303-15.




2020     |     www.medigraphic.com