medigraphic.com

2013, Number 3

<< Back Next >>

Rev Med MD 2013; 4.5 (3)

Role of the microRNA in the idiopathic ulcerative colitis

De-León-Rendón JL, Yamamoto-Furusho JK

Language: Spanish
References: 64
Page: 174-180
PDF size: 609.78 Kb.


ABSTRACT

The idiopathic ulcerative colitis (IUC)is a disease of multifactorial origin, chronic and incurable characterized by remissions and exacerbations. Despite amplifying the knowledge on the cellular and molecular mechanisms of the intestinal inflammation, its etiology and pathogenesis are unknown. The microRNA (miRNA) are small regions of RNA of simple chain, non-coding, involved in the post-transcriptional regulation of 30% of the protein codifying genes. The evidence described stand out the important role of the miRNA as contributors to the susceptibility of the ICU, noting the importance as means of discovery of the disease mechanisms, its diagnosis and therapeutics.


REFERENCES

  1. Podolsky D.K. Inflammatory Bowel Disease. N Engl J Med. 2002 Aug 8;347(6):417-29.

  2. 2.Sartor RB. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterology Clinics of North America 1995; 475-507.

  3. 3.Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115: 182-205.

  4. 4.Morahan G, Morel L. Genetics of autoimmune diseases in humans and in animal models. Curr Opin Immunol 2002; 14: 803-11.

  5. 5.Cho J. Update on inflammatory bowel disease genetics. Curr Gastroenterol Rep 2000; 2: 434-9.

  6. 6.Yamamoto Furusho JK. Immunogenetics of chronic ulcerative colitis. Rev Invest Clin 2003; 55(6): 705-10.

  7. 7.G. Gallagher. Interleukin-19: Multiple roles in immune regulation and disease. Cytokine & Growth Factor Reviews 2010; 21:345–352.

  8. 8.Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281-297.

  9. 9.Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843-854.

  10. 10.Wightman B, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75:855-862.

  11. 11.Reinhart BJ, Slack FJ, Basson M, et al. The 21- nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403:901-906.

  12. 12.Pasquinelli AE, Reinhart BJ, Slack F, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000; 408:86-89.

  13. 13.Griffiths-Jones S, Saini HK, van Dongen S, Bateman A, Enright AJ. miRBase: tools for microRNA genomics. Nucleic Acids Res. 2008;36: D154-D158.

  14. 14.Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001;294: 853-858.

  15. 15.Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003;425:415-419.

  16. 16.Han J, Lee Y, et al. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 2004;18:3016-3027.

  17. 17.Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U. Nuclear export of microRNA precursors. Science. 2004;303:95-98.

  18. 18.Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell. 2003;115:209-216.

  19. 19.Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc Natl Acad Sci USA. 2003;100:9779-9784.

  20. 20.Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15-20.

  21. 21.Guarnieri DJ, DiLeone RJ. MicroRNAs: a new class of gene regulators. Ann Med. 2008;40:197-208.

  22. 22.Jiang X, Tsitsiou E, Herrick SE, Lindsay MA. MicroRNAs and the regulation of fibrosis. FEBS J. 2010;277:2015-2021.

  23. 23.Garzon R, Calin GA, Croce CM. MicroRNAs in cancer. Annu Rev Med. 2009;60:167-169.

  24. 24.Malumbres R, Sarosiek KA, Cubedo E, et al. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood. 2009;113:3754-3764.

  25. 25.Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med. 2005;353:1793-1801.

  26. 26.Lu LF, Liston A. MicroRNA in the immune system, microRNA as an immune system. Immunology. 2009;127:291-298.

  27. 27.Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003; 21:335-376.

  28. 28.Dunne A, O'Neill LA. Adaptor usage and Toll-like rece ptor signaling specificity. FEBS Lett. 2005;579:3330-3335.

  29. 29.Kracht M, Saklatvala J. Transcriptional and posttranscriptional control of gene expression in inflammation. Cytokine. 2002; 20: 91-106.

  30. 30.O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D. MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A. 2007;104:1604-1609.

  31. 31.Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-kB dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103:12481-12486.

  32. 32.Tili E, Michaille JJ, Cimino A, et al. Modulation of mi R - 155 and mi R - 125 bleve lsfollow inglipopolysaccharide/TNFa stimulation and their possible roles in regulating the reponse to endotoxin shock. J Immunol. 2007;179:5082-5089.

  33. 33.Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303: 83-86.

  34. 34.Zhou B, Wang S, et al. miR-150, a microRNAexpressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A. 2007;104:7080-7085.

  35. 35.Wu H, Neilson JR, Kumar P, et al. miRNA profiling of naive, effector and memory CD8 T cells. PLoS One. 2007;2: e1020.

  36. 36.Sonkoly E, Wei T, Janson PC, et al. MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? PLoS One. 2007;2: e610.

  37. 37.Stanczyk J, Pedrioli DM, Brentano F, et al. Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 2008;58:1001-1009.

  38. 38.Nakasa T, Miyaki S, Okubo A, et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 2008;58:1284-1292.

  39. 39.Tan Z, Randall G, Fan J, et al. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet. 2007;81:829-834.

  40. Dai Y, Huang YS, Tang M, et al. Microarray analysis of microRNA expression in peripheral blood cells of systemic lupus erythematosus patients. Lupus. 2007;16:939-946.

  41. 41.Dai Y, Sui W, et al. Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int. 2009;29:749- 754.

  42. 42.Lowes MA, Bowcock AM, Kr ueger JG. Pathogenesis and therapy of psoriasis. Nature. 2007;445:866-873.

  43. 43.Ichihara A, Jinnin M, Oyama R, et al. Increased serum levels of miR-1266 in patients with psoriasis vulgaris. Eur J Dermatol. 2011 Nov 30. [Epub ahead of print].

  44. 44.Tang Y, Luo X, Cui H, et al. MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins. Arthritis Rheum. 2009;60:1065-1075.

  45. 45.Sushila R. Dalal, John H. Kwon. The Role of MicroRNA in Inflammatory Bowel Disease. Gastroenterology & Hepatology 2010; 11(6).

  46. 46.Glinsky GV. An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway. Cell Cycle. 2008;7:2570-2583.

  47. 47.Glinsky GV. Disease phenocode analysis identifies SNP-guided microRNA maps (MirMaps) associated with human “master” disease genes. Cell Cycle. 2008; 7:3680-3694.

  48. 48.Fasseu M, Treton X, et al. Identification of Restricted Subsets of Mature microRNA Abnormally Expressed in Inactive Colonic Mucosa of Patients with Inflammatory Bowel Disease. PLoS ONE 2010; 5(10): e13160. doi:10.1371/journal.pone.0013160.

  49. 49.Xu H, Cheung IY, Guo HF, Cheung NK. MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors. Cancer Res 2009; 69: 6275–81.

  50. 50.Kota J, Chivukula RR, et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005–17.

  51. 51.Flavin R, Smyth P, et al. miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. Int J Gynecol Cancer 2009; 19: 641–7.

  52. 52.Sander S, Bullinger L, Wirth T. Repressing the repressor: a new mode of MYC action in lymphomagenesis. Cell Cycle 2009; 8: 556–9.

  53. 53.Yan LX, Huang XF, et al. MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. Rna 2008; 14: 2348–60.

  54. 54.Ferretti E, De Smaele E, et al. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. Embo J 2008; 27: 2616–27.

  55. 55.Gebeshuber CA, Zatloukal K, Martinez J. miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep 2009;10: 400–5.

  56. 56.Musiyenko A, Bitko V, Barik S. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates prostein translation and invasiveness of prostate cancer LNCaP cells. J Mol Med 2008; 86: 313–22.

  57. 57.Park SY, Lee JH, Ha M, Nam JW, Kim VN. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol 2009; 16: 23–9.

  58. 58.Li Z, Lu J, et al. Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A 2008;105: 15535–40.

  59. 59.Zhou Q, Souba WW, Croce CM, Verne GN. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut 2010; 59: 775–84.

  60. 60.Hollander D. Intestinal permeability, leaky gut, and intestinal disorders. Curr Gastroenterol Rep.1999; 1: 410–6.

  61. 61.Bian Z, Li L, et al. Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. J Pathol. 2011; 225(4):544-53. doi: 10.1002/path.2907.

  62. 62.Pauley KM, Satoh M, et al. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008;10:R101.

  63. 63.Te JL, Dozmorov IM, et al. Identification of unique microRNA signature associated with lupus nephritis. PLoS One. 2010;5:e10344.

  64. 64.Wu F, Guo NJ, et al. Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohn's disease. Inflamm Bowel Dis. 2010 Sept 1; Epub ahead of print.




2020     |     www.medigraphic.com