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2013, Número 3

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Rev Med MD 2013; 4.5 (3)


Papel de los microARN en la Colitis Ulcerosa Crónica Idiopática

De-León-Rendón JL, Yamamoto-Furusho JK

Idioma: Español
Referencias bibliográficas: 64
Paginas: 174-180
Archivo PDF: 609.78 Kb.


RESUMEN

La Colitis Ulcerosa Crónica Idiopática (CUCI) es una enfermedad de origen multifactorial, de curso crónico e incurable que se caracteriza por remisiones y exacerbaciones. A pesar de ampliar el conocimiento de los mecanismos celulares y moleculares de la inflamación intestinal, su etiología y patogénesis son desconocidas. Los microARN (miARN) son pequeñas regiones de ARN de cadena sencilla, no codificantes, implicadas en la regulación post-transcripcional del 30% de los genes codificadores de proteínas. Las evidencias descritas destacan el importante papel de los miARN como contribuyentes a la susceptibilidad de la CUCI. El objetivo del presente trabajo es revisar el papel de los miARN en la CUCI y destacar su importancia como vía para el descubrimiento de los mecanismos de la enfermedad, su diagnóstico y terapéutica.


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