2009, Number 4
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Rev Invest Clin 2009; 61 (4)
Inflammaging Aging inflammatory origin
Navarrete-Reyes AP, Montaña-Álvarez M
Language: Spanish
References: 54
Page: 327-336
PDF size: 346.15 Kb.
ABSTRACT
The association between the increase in life expectancy in hu
mans and age related changes in the immune system pro
motes that individuals are exposed longer to endogenous and
environment antigens which allows an activation of the in
nate immune system and the subsequent establishment of a
low grade chronic inflammation state with an increased ex
pression of proinflammatory cytokines (tumor necrosis factor
alpha, interleukin 6, etc.). This inflammatory state referred as
inflammaging is characterized by a inflammatory origin of
aging given by the activation of cellular systems responsible
of gene promotion and suppression as the nuclear factor kap
pa B, sirtuins, forkhead box O and KLOTHO, who are directly
or indirectly involved in cellular mechanisms of resistance to
oxidative stress, apoptosis and nucleic acids transcriptional
mistakes repair. The activation of these cellular systems is as
sociated with the pathogenesis of several chronic and degene
rative diseases such as Alzheimer’s disease, late onset diabetes
or cardiovascular diseases. However, we are placed in a cross
road because we can not establish whether this inflammatory
state observed in the aging process is responsible of develop
ment of degenerative diseases or if the presences of these
chronic diseases are responsible for this inflammatory state
of aging. Evidence in centenarians who are healthy and have
preserved functional status has shown that there is a chronic
inflammatory state present among them but is balanced by a
higher expression of anti inflammatory molecules.
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