Puente A, Alexánderson E, Arroyo A, Lorenzo A, Victoria D

Language: Spanish
References: 21
Page: 448-455
PDF size: 265.60 Kb.

ABSTRACT

Gated SPECT is a useful technique to evaluate myocardial perfusion, wall motion abnormalities and wall thickening. There is not published experience in Latin-America using dual isotope rest Thallium-201/stress Tc-99m Tetrofosmin Gated SPECT. Method: We studied 27 patients with coronary artery disease. Coronary angiography was performed in all the patients. We used an injection at rest of 3 mCi of Thallium-201 followed by stress and the administration of 15 mCi of Tetrofosmin and Gated SPECT acquisition. Five days after, the patients were injected with 20 mCi of Sestamibi at stress, with a second Gated SPECT acquisition. Perfusion data were analyzed using 20 SPECT segment analysis. To study the wall motion, we divided the heart in 29 segments and every segment was scored using a 4 points scale (3=normal, 2=mild hipokinesia, 1=severe hipokinesia, 0= akinesia). Results: The perfusion and wall motion segmental score agreement between stress Tc-99m tetrofosmin and stress Tc-99m sestamibi were 97% and 84% respectively. Conclusions: Rest Thailium-201/stress Tc-99m Tetrofosmin Dual isotope Gated SPECT technique is a good protocol to assess simultaneous myocardial perfusion and wall motion. There is a good agreement of the results with the use of rest Thallium-201/stress Tc-99m Sestamibi Dual isotope Gated SPECT study.

REFERENCES

1. Braunwald E: Cardiología Nuclear. Tratado de Cardiología. Madrid, España. Interamericana-McGraw-Hill 1993; 1: 305-345.

2. Puente A, Alexanderson E, Villavicencio R, Bialostosky D, Victoria D, Arroyo A: Utilidad del SPECT (Tomografía Computada por Emisión de Foton único) en la detección de enfermedad aterosclerosa coronaria. Arch Inst Cardiol 1997; 67: 384-390.

3. Berman Daniel: Introduction-Technetium-99m myocardial perfusion imaging agents and their relation to thalliium-201. Am J Cardiol 1990; 16: 1E-4E.

4. Kelly D, Forster A, Higley B, Archer C, Booker F, Canning L, et al: Technetium-99m-tetrofosmin as a new radiopharmaceutical for miocardial perfusion imaging. J Nucl Med 1993; 34: 222-227.

5. Nakajima K, Taki J, Shuke N, Bunko H, Takata S, Hisada K: Miocardial perfusion imaging and dynamic analysis with Technetium-99m Tetrofosmin. J Nucl Med 1993; 34: 1478-1484.

6. Sinusas A, Shi O, Saltzberg M, Vitois P, Jain D, Wackers F, et al: Technetium-99m-Tetrofosmin to asses myocardial Blood Flow: Experimental validation in an intact canine model of ischemia. J Nucl Med 1994; 35: 664-671.

7. Jain D, Wackers F, Mattera J, Mc Mahon M, Sinusas A, Zaret B: Biokinetics of Technetium-99m-Tetrofosmin: Miocardial perfusion imaging agent: Implications for a one-day imaging protocol. J Nucl Med 1993; 34: 1254-1259.

8. Schulz G, Ostwald E, Kaiser H, Von Dahl J, Kleinhans E, Buell U: Cardiac stress-rest single-photon emission computed tomography with technetium 99m-labeled Tetrofosmin: influence of washout kinetics on regional myocardial uptake values of the rest study with a 1-day protocol. J Nucl Cardiol 1997; 4: 298-301.

9. Flamen P, Bossuyt A, Franken P: Technetium-99-m Tetrofosmin in Dipyridamole-stress myocardial SPECT imaging: Intraindividual comparision with Technetium-99-m Sestamibi. J Nucl Med 1995; 36: 2009-2015.

10. Sridhara B, Braat S, Rigo P, Itti R, Cload P, Lahiri A: Comparison of myocardial perfusion imaging with Technetium-99m Tetrofosmin versus Thallium-201 in coronary artery disease. Am J Cardiol 1993; 72: 1015-1019.

11. Rigo P, Leclerq B, Roland I, Lahiri A, Braat S. Technetium-99-Tetrofosmin Myocardial imaging: A comparison with Thallium-201 and Angiography. J Nucl Med 1994; 35: 587-593.

12. Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A: Myocardial perfusion imaging with 99m Tc Tetrofosmin. Comparison to 201 Thailium imaging and coronary angiography in a Phase III Multicenter Trial. Circulation 1995; 91: 313-319.

13. Khattar R, Endel R, Crawley J, Wackers F, Rigo P, Zaret B, et al: Improved diagnostic accuracy o planar imaging with techentium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. J Nucl Cardiol 1997; 4: 291-7.

14. Benoit Th., Vivegnis D, Lahiri A: Tomographic miocardial imaging with technetium-99m tetrofosmin. Eur Heart J 1996; 17: 635-642.

15. Moahmood S, Gunning M, Bomanji, Costa DC, Jarrit P, Swanton H, et al: Combined rest thallium-201/stress technetium-99m-tetrofosmin SPECT: Feasibility and diagnostic accuracy of a 90-minute protocol. J Nucl Med 1995; 36: 932-935.

16. Fukuzawa S, Inagaki M, Morooka S, Inove T, Matsumoto Y, Yokoyama K, et al: Evaluation of myocardial viability using sequential Dual-isotope Single Photon Emission Tomography Imaging with rest TI-201/stress Tc-99 Tetrofosmin in the prediction of wall motion recovery after revascularization. Jpn Circ J 1997; 61: 481-487.

17. Maddahi J, Rodrigues E, Berman D, Kiat Hosen: State-of-the-art myocardial perfusion imaging. In: Cardiology Clinics 1994; 12: 199-222.

18. De Puey E, Berman D, Garcia E: Cardiac SPECT Imaging. New York, USA. Raven Press 1994; 103-19.

19. Germano G, Kiat H, Kavanagh P, Moriel M, Mazzanti M, Te Su H, et al: Automatic Quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 1995; 36: 2138-2147.

20. Germano G, Kavanagh P, Berman D: Effect of the number of proyections collected on quantitative perfusion and left ventricular ejection fraction measurements from gated myocardial Perfusion single-photon emission computed tomographic images. J Nucl Cardiol 1996; 3: 395-402.

21. Berman D, Germano G: Evaluation of ventricular ejection fraction, wall motion, wall thickening and other parametres with gated mocardial perfusion single-photon emission computed tomography. J Nucl Cardiol 1997; 4: S169-S171.