Olay FG, Díaz PP, Hernández GR, Cervantes-Villagrana RD, Presno-Bernal JM, Alcántara GLE

Language: Spanish
References: 25
Page: 43-51
PDF size: 102.85 Kb.

ABSTRACT

The medical interpretation of clinical results is a fundamental practice in the decision making process respect to patient management, in this process is necessary to compare the result against the reference range calculated for the patient population. The aim of this study was to determine the reference intervals of different clinical chemistry analytes in the Mexican population. Results of 653,467 individuals of both genders were analyzed. We used the nonparametric method of Tukey for detection of extreme values and reference intervals determined by the nonparametric method recommended by the CLSI in C28-A3 guide. Variations were observed between the calculated reference intervals and those submitted in the insert of different analytes: metabolites such as urea and blood urea nitrogen, enzymes as alanine aminotransferase, gamma glutamyl transpeptidase and lactate dehydrogenase, and electrolytes as chlorine, phosphorus and magnesium showed higher concentration intervals. Reference intervals of clinical trials analyzed, in some cases, show differences with respect to the ranges suggested by insert, and can even differ from values suggested by international associations. Therefore, it is advisable to determine reference intervals in each clinical laboratory.

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