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Revista de la Asociación Médica del Centro Médico ABC

2013, Number 1

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An Med Asoc Med Hosp ABC 2013; 58 (1)

Silymarin, alpha-lipoic acid and selenomethionine in the treatment of fatty liver: a systematic review of the literature

Vázquez FR, Reyes GJG, Fernández del Valle LC, Anaya RM, Rizzoli CA

Language: Spanish
References: 72
Page: 37-46
PDF size: 99.80 Kb.


ABSTRACT

The typical histological pattern of alcoholic liver disease is a steatohepatitis. Non-alcoholic fatty liver disease is a common condition frequently found in healthy subjects not affected by any other liver disease and not drinking alcohol. The spectrum of Non-alcoholic fatty liver disease ranges from asymptomatic steatosis to nonalcoholic steatohepatitis and cirrhosis. Although risk factors modification remains the cornerstone of therapy for fatty liver disease, there is, in recent years, a growing evidence of usefulness of alternative medicine. Silybum marianum (milk thistle or silymarin) is currently the most well researched plant in the treatment of liver disease, especially in those caused by oxidative stress (alcoholic and non-alcoholic fatty liver and steatohepatitis, drug and compound induced liver toxicity). The main effects of silymarin are the membrane stabilizing and antioxidant effects, it is able to help the liver cell regeneration; it can decrease the inflammatory reaction and inhibit the fibrogenesis in the liver. These results have been established by experimental and clinical trials. According to open studies, the long administration of silymarin significantly increased the survival time of patients with alcohol-induced liver cirrhosis. There is limited evidence of alpha lipoic acid (thioctic acid), and selenium in the treatment of fatty liver disease.


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