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2013, Number 1

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Med Crit 2013; 27 (1)

Prevalence of vitamin D deficiency in critically ill patients

Carrillo ER

Language: Spanish
References: 19
Page: 33-37
PDF size: 78.45 Kb.


ABSTRACT

Introduction: The incidence of vitamin D deficiency is high in the critically ill patients and is associated with increased morbidity and mortality.
Objective: The aim of the study is to evaluate the prevalence of 25-hydroxyvitamin D deficiency in an Intensive Care Unit (ICU) and its relationship with length of Intensive Care Unit stay, ventilator days and outcome.
Methods: Prospective, observational and descriptive study in an intensive care unit. A total of 50 critically ill patients were included. All patients underwent determination of serum levels of 25 hydroxyvitamin D.
Results: Seventy-eight percent of the sample (36 patients) presented 25-hydroxyvitamin D deficiency, 16% (12 patients) insufficiency and only 6% (3 patients) had normal levels. No correlation was found between vitamin D levels and mortality, length of stay in the Intensive Care Unit and days of mechanical ventilation.
Conclusion: The prevalence of vitamin D deficiency is high in critically ill patients.


REFERENCES

  1. Lips P. Vitamin D physiology. Progress in Biophysics & Molecular Biology 2006; 92: 4-8.

  2. Bickle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009;94:26-34.

  3. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713-716.

  4. Holick MF, Chen TC. Vitamin D deficiency; a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080-1086.

  5. Krishnan A, Ochola J, Venkatesh B. Vitamin D in Critical Illness. In: Vincent JL, ed. Yearbook of intensive care and emergency medicine. Germany: Springer-Verlag; 2010: 273-281.

  6. Goldner WS, Stoner JA, McBride C. Prevalence of vitamin D insufficiency and deficiency in morbidily obese patients: a comparison with non-obese controls. Obes Surg 2008;18:145-150.

  7. Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Díaz FG. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care 2011;15:R292.

  8. Rimaniol JM, Authier J, Chariot P. Muscle weakness in intensive care patients: Initial manifestation of vitamin D deficiency. Intensive Care Med 1994;20:591-592.

  9. Nierman DM, Mechanick JI. Bone Hyperresorption is prevalent in chronically ill patients. Chest 1998;114:1122-1128.

  10. Van der Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcw L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab 2003;88:4623-4632.

  11. Lucidarme O, Messai E, Mazzoni T, Arcade M, Du Cheyron D. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Med 2010;36:1609-1611.

  12. Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med 2009;7:28.

  13. Lee P, Nair P, Eisman JA, Center JR. Vitamin D deficiency in the intensive care unit: an invisible accompliance to morbidity and mortality? Intensive Care Med 2009;35:2028-2032.

  14. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med 2009;360:1912-1914.

  15. McKinney JD, Bailey BA, Garrett LH, Peiris P, Manning T, Peiris A. Relationship between vitamin D status and ICU Outcomes in veterans. J Am Med Dir Assoc 2011; 12: 208-211.

  16. Krishnan A, Ochola J, Mundy J, Jones M, Kruger P, Duncan E. Acute fluid shifts influence the assessment of serum vitamin D status in critically ill patients. Crit Care 2010;14:R216.

  17. Braun A, Chang D, Mahadevappa K, Gibbons FK, Liu Y, Giovannucci E. Association of low serum 25-hydroxytibamin D levels and mortality in the critically ill. Crit Care Med 2011;39:671-677.

  18. Amrein K, Sourij H, Wagner G, Holl A, Pieber TR, Smolle KH. Short term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double blind, placebo-controlled pilot study. Crit Care 2011;15:R014.

  19. Lee P. How deficient are vitamin D deficient critically ill patients? Crit Care 2011;15:154.




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