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2002, Number 4

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Rev Med Hosp Gen Mex 2002; 65 (4)

Reactive hemophagocytic syndrome. A post mortem study of 24 pediatric cases

Morales-Ferrer G, Durán-Padillam MA, Córdova RS

Language: Spanish
References: 23
Page: 207-212
PDF size: 104.72 Kb.


ABSTRACT

Hemophagocytic syndrome is an heterogeneous disease, clinically it presents with fever, anemia pancytopenia or multiple organ failure. Histologically it afects the phagocytic system with the presence of hemophagocytosis in the spleen, liver, lymph nodes and bone marrow. It afects children (1–2/1.000.000) with survival rates of 60%. 24 cases of hemophagocytic syndrome were selected from pediatric pathology autopsy reports and the morphologic changes were studied, concomitant diseases four were acute lymphoblastic leukemia (ALL) 33%, acute myeloid leukemia (AML) 8%, myelodisplastic syndrome (MS) 4%, non–Hodgkin lymphoma 25%. Infectious agents were also four: Salmonella typhi 4%, Staphylococcus epidermidis 8%, Klebsiella 4%, Candida albicans 4%, Epstein-Barr virus 4% and hepatitis B virus 4%. Intense histiocytosis associated with leukemias and lymphomas was prominent in lymph node and bone marrow fatal cases were related to Epstein-Barr virus (+) T–cell lymphoma, acute lymphocytic leukemia and hepatitis B. We conclude that pathologic examination of lymph nodes and bone marrow is a useful tool for the diagnosis of hemophagocytic syndrome.


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