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ISSN 1561-3011 (Electronic)

2012, Number 3

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Rev Cubana Invest Bioméd 2012; 31 (3)

Representation of the development of the primary spongiosa by means of a reaction-diffusion system: a hypothesis on the onset of immature bone formation. Part 1: Model description

López-Vaca OR, Garzón-Alvarado DA

Language: Spanish
References: 24
Page: 290-296
PDF size: 78.98 Kb.


ABSTRACT

A biochemical model is presented which predicts the formation of the architecture of the primary spongiosa, based on the interaction of two molecular factors: VEGF (vascular endothelial growth factor) and MMP-13 (metalloproteinases-13). It is assumed that MMP-13 regulates cartilage degradation, and VEGF allows vascularization and the advance of the ossification front through the presence of osteoblasts. The coupling of this set of molecules is represented by means of reaction-diffusion equations with Turing space parameters, and a stable spatio-temporal pattern is obtained which leads to the formation of the trabeculae present in the spongy tissue.


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