Coyoy SA, Morán J

Language: Spanish
References: 21
Page: 100-109
PDF size: 878.51 Kb.

ABSTRACT

Reactive oxygen species (ROS) are generated by several sources. It has been suggested that NADPH oxidase (NOX) participates in the production of ROS that are involved in many physiological and pathological processes. There are 7 homologues of the NOX, whose primary function is the ROS production. The distribution of the members of the NOX family in the tissues and cells is widespread. NOX participates in the host defense, cell death, proliferation and differentiation, through mechanisms that include cellular signaling, regulation of gene expression, posttranslational processing of proteins, etc. Also, the alteration of NOX expression or activity can lead to a series of pathological processes. In this review we will address some of these processes.

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