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2012, Number 5

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Salud Mental 2012; 35 (5)

Contaminantes ambientales neurotóxicos cercanos a nuestra vida diaria

León-Olea M, Sánchez-Islas E, Mucio-Ramírez S, Miller-Pérez C, Garduño-Gutiérrez R

Language: Spanish
References: 98
Page: 395-403
PDF size: 493.90 Kb.


ABSTRACT

Chemical substances play an important role in life quality; they are present in household items and consumer products like furniture, cloths, toys, etc. However some of these substances could be dangerous for health and environment. Among the best known are the organohalogens pollutants like the polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). These substances persist in the enviroment, they bioaccumulate and may cause adverse effects in humans health. There is increasing evidence that organohalogens cause neurotoxicity in rats and human brains during development. We have been studying the neurotoxicity of Aroclor 1254 (PCB mixture) and DE-71 (PBDE mixture) in collaboration with Currás-Collazo team (UC-MEXUS/CONACYT grants). We show in this paper the principal results of our research related with molecules that participate in the osmoregulatory system, learning and memory as vasopressin, PACAP and nitric oxide synthase. We exposed pregnant rats to this organohalogens perinatally; the pups were allowed to grow until three months old for an osmotic challenge. Brains were processed for immunflourescence, other group was used to evaluate memory with the passive inhibitory avoidance test and Western-blot was done for presynaptic proteins Synapsin I and Synaptophysin. We found a disruption in the content of VP, PACAP and nNOS suggesting that the PCB and PBDE exposure alter the function of hypothalamic neurons that regulates osmosis and water balance. We demonstrated also that PBDE treatment modifies systolic pressure and plasmatic osmolality compared with controls suggesting a cardiovascular alteration caused by PBDEs. We found an alteration in the nNOS activity in Aroclor-1254 treated rats. Memory test and presynaptic proteins expression showed an important reduction in males, suggesting that PCBs alters the expression and activity of nitric oxide and learning and memory.
Therefore, due to the neurotoxicity of the organohalogens and its constant contact with humans there is a big concern about the lack of adequate legislation in Mexico and monitoring programs to evaluate the degree of contamination in the population, especially in infants as well as the regions most affected by such contamination.


REFERENCES

  1. Katsuki S. Reports of the study groups for “Yusho” (chlorobiphenyls poisoning). Fukuoka Acta Med 1969;60:403-553.

  2. Nagayama J, Kuratsune M, Masuda Y. Determination of chlorinated dibenzofurans in Kanechlors and “Yusho oil”. Bull Environ Contam Toxicol 1976;15:9-12.

  3. Miyata H, Kashimoto T, Kunita N. Studies on the compounds related to PCB. (V) Detection and determination of unknown organochlorinated compounds in Kanemi rice oil causing “Yusho.” J Food Hyg Soc 1978;19:364-371.

  4. Schecter A, Stanley J, Boggess K, Masuda Y et al. Polychlorinated biphenyl levels in the tissues of exposed and nonexposed humans. Environ Health Perspect 1994;102:149-158.

  5. Swanson GM, Ratcliffe HE, Fischer LJ. Human exposure to polychlorinated biphenyls (PCBs): a critical assessment of the evidence for adverse healtheffects. Regul Toxicol Pharmacol 1995;21:136-150.

  6. Weinand-Harer et al. Behavioral effects of maternal exposure to an ortho-chlorinated or a coplanar PCB congener in rats. Environmental Toxicology Pharmacology 1997;3:97-103.

  7. Van den Berg M, Birnbaum LS, Denison M, De Vito M et al. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006; 93:223-241.

  8. Mochida Y, Fukata H, Matsuno Y, Mori C. Reduction of dioxins and polychlorinated biphenyls (PCBs) in human body. Fukuoka Igaku Zasshi 2007; 98:106-113.

  9. Revich BA, Shelepchikov AA. [Environmental contamination with permanent organic pollutants and human health]. Gig Sanit 2008; 4:26-32.

  10. Watanabe S, Kitamura K, Nagahashi M. Effects of dioxins on human health: a review. J Epidemiol 1999; 9:1-13.

  11. Weber R, Gaus C, Tysklind M, Johnston P et al. Dioxin- and POP-contaminated sites--contemporary and futurerelevance and challenges: overview on background, aims and scope of the series. Environ Sci Pollut Res Int 2008; 15:363-393.

  12. Huwe J, Pagan-Rodriguez D, Abdelmajid N, Clinch N et al. Survey of polychlorinated dibenzo-p-dioxins,polychlorinated dibenzofurans, and non-ortho-polychlorinated biphenyls in U.S. meat and poultry, 2007- 2008: effect of new toxic equivalency factors on toxic equivalency levels, patterns, and temporal trends. J Agric Food Chem 2009; 57:11194-200.

  13. Breivik K, Sweetman A, Pacyna JM, Jones KC. Towards a global historical emission inventory for selected PCB congeners--a mass balance approach 3. An update Sci Total Environ 2007; 377:296-307,

  14. Wiseman SB, Wan Y, Chang H, Zhang X et al. Polybrominated diphenyl ethers and their hydroxylated/methoxylated analogs: environmental sources, metabolic relationships, and relative toxicities. Mar Pollut Bull 2011; 63:179-188.

  15. Covaci A, Harrad S, Abdallah MA, Ali N et al. Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour. Environ Int 2011; 37:532-556.

  16. Król S, Zabiegała B, Namieśnik J. PBDEs in environmental samples: sampling and analysis. Talanta 2012; 93:1-17.

  17. Birnbaum LS, Cohen Hubal EA. Polybrominated diphenyl ethers: a case study for using biomonitoring data to address risk assessment questions. Environ Health Perspect 2006; 114:1770-775.

  18. Hale RC, La Guardia MJ, Harvey E, Gaylor MO et al. Brominated flame retardant concentrations and trends in abiotic media. Chemosphere 2006; 64:181-186.

  19. Harrad S, Ibarra C, Diamond M, Melymuk L et al. Polybrominated diphenyl ethers in domestic indoor dust from Canada, New Zealand, United Kingdom and United States. Environ Int 2008; 34:232-238.

  20. Abdallah MA, Harrad S, Covaci A. Isotope dilution method for determination of polybrominated diphenyl ethers using liquid chromatography coupled to negative ionization atmospheric pressure photoionization tandem mass spectrometry: validation and application to house dust. Anal Chem 2009; 81:7460-467.

  21. Lagalante AF, Oswald TD, Calvosa FC. Polybrominated diphenyl ether (PBDE) levels in dust from previously owned automobiles at United States dealerships. Environ Int 2009; 35:539-544.

  22. Safe SH. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 1994; 24:87–149.

  23. Petreas M, She J, Brown FR, Winkler J et al. High body burdens of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) in California women. Environ Health Perspect 2003; 111:1175-1179.

  24. Hites RA, Foran JA, Schwager SJ, Knuth BA et al. Global assessment of polybrominated diphenyl ethers in farmed and wild salmon. Environ Sci Technol 2004; 38:4945–4949.

  25. Yogui GT, Sericano JL. Polybrominated diphenyl ether flame retardants in the U.S. marine environment: a review. Environ Int 2009; 35:655-666.

  26. Wu N, Herrmann T, Paepke O, Tickner J et al. Human exposure to PBDEs: associations of PBDE body burdens with food consumption and house dust concentrations. Environ Sci Technol 2007; 41:1584-1589.

  27. Roosens L, Abdallah MA, Harrad S, Neels H et al. Factors influencing concentrations of polybrominated diphenyl ethers (PBDEs) in students from Antwerp, Belgium. Environ Sci Technol 2009; 43:3535-3541.

  28. Hagmar L. Polychlorinated biphenyls and thyroid status in humans: a review. Thyroid 2003; 13:1021–1028.

  29. Cromwell HC, Johnson A, McKnight L, Horinek M, Asbrock C et al. Effects of polychlorinated biphenyls on maternal odor conditioning in rat pups. Physiol Behav 2007; 91:658–666.

  30. Corey DA, Juárez de Ku LM, Bingman VP, Meserve LA. Effects of exposure to polychlorinated biphenyl (PCB) from conception on growth, and development of endocrine, neurochemical, and cognitive measures in 60 day old rats. Growth Dev Aging 1996; 60:131-143.

  31. Schantz SL, Seo BW, Wong PW, Pessah IN. Long-term effects of developmental exposure to 2,2’,3,5’,6-pentachlorobiphenyl (PCB 95) on locomotor activity, spatial learning and memory and brain ryanodine binding. Neurotoxicology 1997; 18:457-467.

  32. Donahue DA, Dougherty EJ, Meserve LA. Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats. Toxicology 2005; 203:99-107.

  33. Colciago A, Casati L, Mornati O, Vergoni AV et al. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the offspring. Toxicol Appl Pharmacol 2009; 239:46-54.

  34. Kodavanti PR, Osorio C, Royland JE, Ramabhadran R et al. Aroclor 1254, a developmental neurotoxicant, alters energy metabolism- and intracellular signaling-associated protein networks in rat cerebellum and hippocampus. Toxicol Appl Pharmacol 2011; 256:290-299.

  35. Peltola V, Mäntylä E, Huhtaniemi I, Ahotupa M. Lipid peroxidation and antioxidant enzyme activities in the rat testis after cigarette smoke inhalation or administration of polychlorinated biphenyls or polychlorinated naphthalenes. J Androl 1994; 15:353-361.

  36. Carpenter DO. Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health. Rev Environ Health 2006; 21:1-23.

  37. Nau H. [Impacts and impact mechanisms of “dioxins” in humans and animals]. Dtsch Tierarztl Wochenschr 2006; 113:292-297.

  38. Boucher O, Muckle G, Bastien CH. Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis. Environ Health Perspect 2009; 117:7-16.

  39. Revich BA, Shelepchikov AA. Environmental contamination with permanent organic pollutants and human health. Gig Sanit 2008; 4:26-32.

  40. Miller–Pérez C, Sánchez–Islas E, Mucio–Ramírez S, Mendoza–Sotelo J et al. Los contaminantes ambientales bifenilos policlorinados (PCB) y sus efectos sobre el Sistema Nervioso y la salud. Salud Mental 2009; 32:335-346.

  41. Crinnion WJ. Polychlorinated biphenyls: persistent pollutants with immunological, neurological, and endocrinological consequences. Altern Med Rev 2011; 16:5-13.

  42. Kodavanti PR, Derr-Yellin EC, Mundy WR, Shafer TJ et al. Repeated exposure of adult rats to Aroclor 1254 causes brain region-specific changes in intracellular Ca2+ buffering and protein kinase C activity in the absence of changes in tyrosine hydroxylase. Toxicol Appl Pharmacol 1998; 153:186-198.

  43. Kodavanti PR, Tilson HA. Neurochemical effects of environmental chemicals: in vitro and in vivo correlations on second messenger pathways. Ann N Y Acad Sci 2000; 919:97-105.

  44. Sharma R, Derr-Yellin EC, House DE, Kodavanti PR. Age-dependent effects of Aroclor 1254R on calcium uptake by subcellular organelles in selected brain regions of rats. Toxicology 2000; 156:13-25.

  45. Kater SB, Mills LR. Regulation of growth cone behavior by calcium. J Neurosci 1991; 11:891-899.

  46. Abeliovich A, Paylor R, Chen C, Kim JJ et al. PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning. Cell 1993; 75:1263-1271.

  47. Kodavanti PR, Ward TR. Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro. Toxicol Sci 2005; 85:952-962.

  48. López D, Athanasiadou M, Athanassiadis I, Yáñez L et al. A Preliminary study on PBDEs and HBCDD in blood and milk from Mexican women. Kyoto, Japan: Fifth international symposium on brominated flame retardants Abstract; 2010.

  49. Martínez L. Evaluación de la exposición de compuestos bromados (PBDEs) en niños de CD. Juárez Chihuahua y niños de dos poblaciones del estado de San Luís Potosí. Tesis de Maestría: Facultad de Medicina, Universidad Autónoma de San Luís Potosí; 2007.

  50. Pérez-Maldonado IN, Ramírez-Jiménez M del R, Martínez-Arévalo LP, López-Guzmán OD et al. Exposure assessment of polybrominated diphenyl ethers (PBDEs) in Mexican children. Chemosphere 2009; 75:1215-1220.

  51. Doris PA. Vasopressin and central integrative processes. Neuroendocrinology 1984; 38:75-85.

  52. Ludwig M. Functional role of intrahypothalamic release of oxytocin and vasopressin: consequences and controversies. Am J Physiology 1995; 268:E537-E545.

  53. Stricker EM, Huang W, Sved AF. Early osmoregulatory signals in the control of water intake and neurohypophyseal hormone secretion. Physiol Behavior 2002; 76:415-421.

  54. Sladek CD, Somponpun SJ. Estrogen receptors: their roles in regulation of vasopressin release for maintenance of fluid and electrolyte homeostasis. Front Neuroendocrinology 2008; 29:114-127.

  55. Kadowaki K, Kishimoto J, Leng G, Emson PC. Up-regulation of nitric oxide synthase (NOS) gene expression together with NOS activity in the rat hypothalamo-hypophysial system after chronic salt loading: Evidence of a neuromodulatory role of nitric oxide in arginine vasopressin and oxytocin secretion. Endocrinology 1994; 134:1011–1017.

  56. Sabatier N, Shibuya I, Dayanithi G. Intracellular calcium increase and somatodendritic vasopressin release by vasopressin receptor agonists in the rat supraoptic nucleus: Involvement of multiple intracellular transduction signals. J Neuroendocrinol 2004; 16: 221-236.

  57. Gillard ER, Coburn C, Gaertner M, Shahidzadeh A et al. Soluble guanylate cyclase is a critical effector of nitric oxide mediated local vasopressin release in the supraoptic nucleus. Program No. 195.11. Washington, DC: Society for Neuroscience; 2007.

  58. Shibuya I, Noguchi J, Tanaka K, Harayama N et al. PACAP increases the cytosolic Ca2_ concentration and stimulates somatodendritic vasopressin release in rat supraoptic neurons. J Neuroendocrinol 1998;10:31–42.

  59. Jamen F, Alonso G, Shibuya I, Widmer H et al. Impaired somatodendritic responses to pituitary adenylate cyclase-activating polypeptide (PACAP) of supraoptic neurones in PACAP type I -receptor deficient mice. J Neuroendocrinol 2003; 15:871-881.

  60. Gillard ER, León-Olea M, Mucio-Ramírez S, Coburn CG et al. A novel role for endogenous pituitary adenylate cyclase activating polypeptide in the magnocellular neuroendocrine system. Endocrinology 2006; 147:791-803.

  61. Rao KM. Molecular mechanisms regulating iNOS expression in various cell types. J Toxicol Environ Health B Crit Rev 2000; 3:27-58.

  62. Sagar SM, Ferriero DM. NADPH diaphorase activity in the posterior pituitary: relation to neuronal function. Brain Res 1987; 400:348-352.

  63. Powell CM. Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide. Neurobiol Learn Mem 2006; 85:2-15.

  64. Kodavanti PR, Shafer TJ, Ward TR, Mundy WR et al. Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells. Brain Res 1994; 662:75-82.

  65. Villar MJ, Ceccatelli S, Rönnqvist M, Hökfelt T. Nitric oxide synthase increases in hypothalamic magnocellular neurons after salt loading in the rat. An immunohistochemical and in situ hybridization study. Brain Res 1994; 644:273-281.

  66. Ueta Y, Levy A, Chowdrey HS, Lightman SL. Water deprivation in the rat induces nitric oxide synthase (NOS) gene expression in the hypothalamic paraventricular and supraoptic nuclei. Neurosci Res 1995; 23:317-319.

  67. Ueta Y, Levy A, Powell MP, Lightman SL et al. Neuronal nitric oxide synthase gene expression in human pituitary tumours: a possible association with somatotroph adenomas and growth hormone-releasing hormone gene expression. Clin Endocrinol (Oxf) 1998; 49:29-38.

  68. Kodavanti PR, Tilson HA. Neurochemical effects of environmental chemicals: in vitro and in vivo correlations on second messenger pathways. Ann N Y Acad Sci 2000; 919:97-105.

  69. Sharma R, Kodavanti PR. In vitro effects of polychlorinated biphenyls and hydroxy metabolites on nitric oxide synthases in rat brain. Toxicol Appl Pharmacol 2002; 178:127-136.

  70. Mucio-Ramírez S, Miller-Pérez C, Sánchez-Islas E, Currás-Collazo M et al. Derangement of hyphothalamic nitric oxide synthase activity in osmotic stressed rats exposed to aroclor 1254 in utero. Washington,DC: Society for Neuroscience Abstract; 2008.

  71. Omori N, Fukata H, Sato K, Yamazaki K et al. Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells. Hum Exp Toxicol 2007; 26:811-816.

  72. Llansola M, Montoliu C, Boix J, Felipo V. Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms. Chem Res Toxicol 2010; 23:813-820.

  73. Currás-Collazo MC. Nitric oxide signaling as a common target of organohalogens and other neuroendocrine disruptors. J Toxicol Environ Health B Crit Rev 2011; 14:495-536.

  74. Sánchez-Islas E, Garduño-Gutiérrez R, Mucio-Ramírez S, Miller-Pérez C et al. Effect of perinatal exposure to a mixture of polychorinate biphenyls, Aroclor1254, on Nitric oxide synthase, synapsin I, synaptophysin and its repercussion on inhibitory avoidance Learning. Washington DC, USA: Society for Neurocience Abstract; 2011.

  75. León-Olea M, Talavera-Cuevas E, Sánchez-Islas E, Mucio-Ramirez S et al. Effects of polychlorinated biphenyls on nitrergic neurons and nitric oxide synthase activity in rat pups brain. San Diego, CA: Society Neuroscience Abstract; 2004.

  76. Mucio-Ramirez S, Miller-Perez C, Sanchez-Islas E, Leon-Olea M. Effects of in utero exposure to Aroclor 1254 on hypothalamic vasopressin immunoreactivity in osmotic stressed rats. Chicago, IL: Society for Neurocience Abstract; 2009.

  77. Currás-Collazo MC, León-Olea M, Mucio-Ramírez S, Watson-Siroboe A et al. Effects of in uterus exposure to Aroclor 1254 on hypothalamic vasopressin immunoreactivity in osmotic stressed rats. Rouen, France: Neuroendocrine Effects of Endocrine Disruptors Abstract; 2010.

  78. Mucio-Ramírez S, Miller-Pérez C, Sánchez-Islas E, Currás-Collazo M et al. Disruption of hypothalamic PACAP and vasopressin by in utero exposure to DE-71 in osmotic stressed rats. San Diego,CA: Society for Neurocience Abstract; 2010.

  79. Shah A, Coburn CG, Watson-Siriboe A, Whitley R et al. Altered cardiovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs). Toxicol Appl Pharmacol 2011; 256:103-113.

  80. Yang ZH. [Advances in the study of the effect of nitric oxide on longterm potentiation]. Sheng Li Ke Xue Jin Zhan 2000; 31:140-2.

  81. Susswein AJ, Katzoff A, Miller N, Hurwitz I. Nitric oxide and memory. Neuroscientist 2004;10:153-162.

  82. Wang JL, An SC, Tai FD. [Reviews on relationship between nitric oxide and olfactory recognition memory]. Sheng Li Ke Xue Jin Zhan 2004;35:146-149.

  83. Edwards TM, Rickard NS. New perspectives on the mechanisms through which nitric oxide may affect learning and memory processes. Neurosci Biobehav Rev 2007;31:413-425.

  84. Paul V, Ekambaram P. Involvement of nitric oxide in learning & memory processes. Indian J Med Res 2011 ;133:471-478.

  85. Kosower EM. A molecular basis for learning and memory. Proc Natl Acad Sci USA 1972; 69:3292-3296.

  86. Pasinelli P, Ramakers GM, Urban IJ, Hens JJ et al. Long-term potentiation and synaptic protein phosphorylation. Behav Brain Res 1995; 66:53-59.

  87. Weiler IJ, Hawrylak N, Greenough WT. Morphogenesis in memory formation: synaptic and cellular mechanisms. Behav Brain Res 1995; 66:1-6.

  88. Wiersma-Meems R, Van Minnen J, Syed NI. Synapse formation and plasticity: the roles of local protein synthesis. Neuroscientist 2005; 11:228-237.

  89. Kleppisch T, Feil R. cGMP signalling in the mammalian brain: role in synaptic plasticity and behaviour. Handb Exp Pharmacol 2009; 191:549-579.

  90. Costa LG, Giordano G. Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants. Neurotoxicology 2007; 28:1047-1067.

  91. Roze E, Meijer L, Bakker A, Van Braeckel KN et al. Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age. Environ Health Perspect. 2009; 117:1953-1958.

  92. Herbstman JB, Sjödin A, Kurzon M, Lederman SA et al. Prenatal exposure to PBDEs and neurodevelopment. Environ Health Perspect 2010; 118:712-719.

  93. Messer A. Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors. Physiol Behav 2010; 100:245-249.

  94. Mucio-Ramírez S, Miller-Pérez C, Sánchez-Islas E, Currás-Collazo MC et al. Disruption of hypothalamic PACAP and vasopressin by in utero exposure to DE-71 in osmotic stressed rats. San Diego,CA: Society for Neuroscience Abstract; 2010.

  95. Nelson KB, Grether JK, Croen LA, Dambrosia JM et al. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol 2001; 49:597-606.

  96. Dogrukol-Ak D, Tore F, Tuncel N. Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects. Curr Pharm Des 2004; 10:1325-1340.

  97. Masuo Y, Morita M, Oka S, Ishido M. Motor hyperactivity caused by a deficit in dopaminergic neurons and the effects of endocrine disruptors: a study inspired by the physiological roles of PACAP in the brain. Regul Pept 2004; 123:225-234.

  98. Ben-Barak Y, Russell JT, Whitnall MH, Ozato K et al. Neurophysin in the hypothalamo-neurohypophysial system. I. Production and characterization of monoclonal antibodies. J Neuroscience 1985; 5:81-97.




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