Kubisz P, Kotulicŏvá D, Chudý P, Bartošová L, Dobrotová M, Ivanková J

Language: English
References: 25
Page: 99-104
PDF size: 177.74 Kb.

ABSTRACT

Background: SPS is most likely a hereditary, autosomal dominant thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers - adenosine diphosphate (ADP) and/or epinephrine (EPI). It manifests with angina pectoris, acute myocardial infarction (MI), transient cerebral ischemic attacks (TIA), stroke, retinal thrombosis, early pregnancy loss syndrome, peripheral arterial thrombosis, and venous thrombosis, sometimes recurrent under oral anticoagulant therapy.
Case report: We report a case of a patient, who has undergone TIA, was diagnosed SPS type I and uses long-term prophylaxis with lowdose aspirin (100 mg). Her mother had once stroke and twice TIA and her older sister had a spontaneous abortion and both were diagnosed SPS type I. Patient’s both children and her oldest sister had only laboratory diagnosis of SPS type I without clinical manifestation. Two kids of patient’s oldest sister had SPS type II. In our patient and her relatives low dose aspirin prophylaxis appeared to be sufficient based on control aggregometry examination. The only exception was patient’s daughter, where combined therapy with ASA+ticlopidin was required.
Conclusion: There is still a lot of concern about SPS. We believe that this case report and many others support its existence, although it is still a long way out to discover its exact cause.

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