Ruiz-Delgado GJ, Lutz-Presno JA, Alarcón-Urdaneta C, Calderón-García J, Ruiz-Argüelles GJ

Language: English
References: 13
Page: 28-31
PDF size: 68.83 Kb.

ABSTRACT

Between March 1996 and December 2010, a total of 138 patients received an allogeneic stem cell transplantation in the Centro de Hematología y Medicina Interna of the Clinica Ruiz. Patients were stratified according to pretransplantation body mass index (BMI) values: 17 patients had low BMI, 62 had normal BMI and 59 patients had high BMI. Median overall survival (OS) for these three groups were respectively 9, 12 and 22 months. Patients with a low BMI had a lower OS than those with a normal BMI (58-month OS of 24% versus 32%), whereas patients with an increased BMI had a better outcome (median OS of 22 months and 43% OS at 130 months) than those with a normal BMI. Our findings demonstrate a correlation between pretransplantation BMI and posttransplantation survival and should provide insight into how to better manage nutritional support for patients undergoing hematopoietic stem cell transplantation.

REFERENCES

1. Fuji S, Kim SW, Yoshimura K, Akiyama H, Okamoto S, Sao H, Takita J, Kobayashi N, Mori S. Japan Marrow Donor Program.: Possible association between obesity and posttransplantation complications including infectious diseases and acute graft-versus-host disease. Biol Blood Marrow Transplant 2009;15:73-82.

2. Lobato-Mendizábal E, Ruiz-Argüelles GJ, Marín-López A.: Leukaemia and nutrition I. Malnutrition is an adverse prognostic factor in the outcome of treatment of patients with standard-risk acute lymphoblastic leukaemia. Leuk Res 1989;13:899-906.

3. Lobato-Mendizábal E, López-Martínez B, Ruiz-Argüelles GJ. A critical review of the prognostic value of the nutritional status at diagnosis in the outcome of therapy of children with acute lymphoblastic leukemia. Rev Invest Clín Méx 2003; 55:31-35.

4. Gómez-Almaguer D, Ruiz-Argüelles GJ, Ruiz-Argüelles A, González-Llano O, Cantú OE, Hernández NE.: Hematopoietic stem cell allografts using a non-myeloablative conditioning regimen can be safely performed on an outpatient basis. Bone Marrow Transpl 2000;25:131-133.

5. Ruiz-Argüelles A, Orfao A.: Caracterización y evaluación de células totipotenciales en sangre periférica y médula ósea. In Ruiz-Argüelles GJ, San-Miguel JF (editors): Actualización en Leucemias. México: Médica Panamericana, 1996;p:79-82.

6. Pinkel D, Straume T, Gray JW. Cytogenetic analysis using quantitative, high sensitivity fluorescence hybridization. Proc Natl Acad Sci USA 1996;83:2934-2938.

7. Yam P, Petz L, Knowlton R, et al. Use of DNA restriction fragment length polymorphisms to document marrow engraftment and mixed hematopoietic chimerism following bone marrow transplantation. Transplantation 1987;43:399-407.

8. Kaplan EL, Meier P. Nonparametric estimations from incomplete observations. J Am Stat Assoc 1958;53:457-463.

9. Navarro WH, Loberiza FR, Bajorunaite R, van Besien K, Vose JM, Lazarus HM, Rizzo D. Effect of body mass index on mortality of patients with lymphoma undergoing autologous hematopoetic stem cell transplantation. Biol Blood Marrow Transplant 2006;152:541-551.

10. Deeg HJ, Seidel K, Bruemmer B, et al. Impact of patient weight on non-relapse mortality after marrow transplantation. Bone Marrow Transplant 1995;15:461-468.

11. Le Blanc K, Ringden O, Remberger A. A low body mass index is correlated with poor survival after allogeneic stem cell transplantation. Haematologica 2003;88:1044-1052.

12. Viana MB, Murao M, Ramos G, et al. Malnutrition as a prognostic factor in lymphoblastic leukemia: a multivariate analysis. Arch Dis Child 1994;71:304-310.

13. Navarro WH, Agovi MA, Logan BR, Bolwell BJ, et al. Obesity does not preclude safe and effective myeloablative hematopoietic cell transplantation (HCT) for acute myelogenous leukemia (AML) in adults. Biol Blood Marrow Transplant 2010;16:1442-1450.