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2012, Number 2

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Rev Educ Bioquimica 2012; 31 (2)

Estructura y función de las uniones estrechas en la transición epitelio-mesénquima (TEM) y la tumorigénesis del cáncer de mama humano

Jiménez-Salazar JE, González-Núñez L, Königsberg-Fainstein M, Gómez-Quiroz LE, Zentella-Dehesa A, Damián-Matsumura P

Language: Spanish
References: 32
Page: 49-59
PDF size: 384.20 Kb.


ABSTRACT

Breast cancer is the leading cause of cancer death among Mexican women above 25 years old. Fortunately, with early detection the survival rate for breast cancer exceeds 10 years. To enable improvements in its prognosis, early sites of cell migration should be detected before the onset of metastasis; consequently, the study of the intercellular junctions has gained considerable attention. The tight junction (TJ) is one component of cell-to-cell adhesion in epithelial cells that contributes to maintain its polarity. Recently several lines of evidence have suggested that proteins of the occludens complex regulates signaling for favoring cell proliferation, and has more recently been implicated in the epithelial-mesenchymal transition (EMT) during the breast cancer process, and therefore can be used as markers for early detection. In this review the significance of tight junctions and its proteins is discussed, with a focus on the proteins forming the occludens complex directly associated to the human breast cancer metastatic phenotype.


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